1L9K

dengue methyltransferase

1L9K の概要

• エントリーDOI: 10.2210/pdb1l9k/pdb
• 分子名称: RNA-DIRECTED RNA POLYMERASE, SULFATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total)
• 機能のキーワード: methyltransferase fold, complex with s-adenosyl-l-homocysteine, transferase
• 由来する生物種: Dengue virus
• 細胞内の位置: Capsid protein C: Virion (Potential). Peptide pr: Secreted (By similarity). Small envelope protein M: Virion membrane; Multi-pass membrane protein (By similarity). Envelope protein E: Virion membrane; Multi- pass membrane protein (By similarity). Non-structural protein 1: Secreted. Non-structural protein 2A-alpha: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): P12823
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35261.75

構造登録者

Egloff, M.P.,Benarroch, D.,Selisko, B.,Romette, J.L.,Canard, B. (登録日: 2002-03-25, 公開日: 2003-03-25, 最終更新日: 2024-02-14)

• 主引用文献: Egloff, M.P.,Benarroch, D.,Selisko, B.,Romette, J.L.,Canard, B.; An RNA cap (nucleoside-2'-O-) methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization; Embo J., 21:2757-2768, 2002; PubMed: 12032088; DOI: 10.1093/emboj/21.11.2757

実験手法

X-RAY DIFFRACTION (2.4 Å)