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1K6V

LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE

Summary for 1K6V
Entry DOI10.2210/pdb1k6v/pdb
Related1K6C 1K6P 1K6T
DescriptorPOL polyprotein, ACETATE ION, N-[2-HYDROXY-1-INDANYL]-5-[(2-TERTIARYBUTYLAMINOCARBONYL)-4(BENZO[1,3]DIOXOL-5-YLMETHYL)-PIPERAZINO]-4-HYDROXY-2-(1-PHE NYLETHYL)-PENTANAMIDE, ... (4 entities in total)
Functional Keywordsindinavir, inhibitor recognition, drug resistance, hiv-1 protease, hydrolase
Biological sourceHuman immunodeficiency virus 1
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P35963
Total number of polymer chains2
Total formula weight22570.51
Authors
Schiffer, C.A. (deposition date: 2001-10-17, release date: 2002-02-06, Last modification date: 2023-08-16)
Primary citationKing, N.M.,Melnick, L.,Prabu-Jeyabalan, M.,Nalivaika, E.A.,Yang, S.S.,Gao, Y.,Nie, X.,Zepp, C.,Heefner, D.L.,Schiffer, C.A.
Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease.
Protein Sci., 11:418-429, 2002
Cited by
PubMed: 11790852
DOI: 10.1110/ps.2520102
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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