1JWP

Structure of M182T mutant of TEM-1 beta-lactamase

Summary for 1JWP

Entry DOI	10.2210/pdb1jwp/pdb
Descriptor	BETA-LACTAMASE TEM, PHOSPHATE ION (3 entities in total)
Functional Keywords	protein stability, tem-1, beta-lactamase, antibiotic resistance, evolution, hydrolase
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	29006.88
Authors	Wang, X.,Minasov, G.,Shoichet, B.K. (deposition date: 2001-09-04, release date: 2002-06-05, Last modification date: 2023-08-16)
Primary citation	Wang, X.,Minasov, G.,Shoichet, B.K. Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs. J.Mol.Biol., 320:85-95, 2002 Cited by PubMed: 12079336 DOI: 10.1016/S0022-2836(02)00400-X PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation