1IS0
Crystal Structure of a Complex of the Src SH2 Domain with Conformationally Constrained Peptide Inhibitor
Summary for 1IS0
Entry DOI | 10.2210/pdb1is0/pdb |
Related PRD ID | PRD_000345 |
Descriptor | Tyrosine-protein kinase transforming protein SRC, AY0 GLU GLU ILE peptide (3 entities in total) |
Functional Keywords | conformationaly constrained inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Rous sarcoma virus More |
Total number of polymer chains | 4 |
Total formula weight | 25746.68 |
Authors | Davidson, J.P.,Lubman, O.,Rose, T.,Waksman, G.,Martin, S.F. (deposition date: 2001-11-02, release date: 2002-02-06, Last modification date: 2023-12-27) |
Primary citation | Davidson, J.P.,Lubman, O.,Rose, T.,Waksman, G.,Martin, S.F. Calorimetric and structural studies of 1,2,3-trisubstituted cyclopropanes as conformationally constrained peptide inhibitors of Src SH2 domain binding. J.Am.Chem.Soc., 124:205-215, 2002 Cited by PubMed: 11782172DOI: 10.1021/ja011746f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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