1IKX
K103N Mutant HIV-1 Reverse Transcriptase in Complex with the Inhibitor PNU142721
Summary for 1IKX
Entry DOI | 10.2210/pdb1ikx/pdb |
Descriptor | POL POLYPROTEIN, 6-CHLORO-2-(1-FURO[2,3-C]PYRIDIN-5-YL-ETHYLSULFANYL)-PYRIMIDIN-4-YLAMINE, ... (4 entities in total) |
Functional Keywords | heterodimer, protein-inhibitor complex, transferase |
Biological source | Human immunodeficiency virus 1 More |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366 |
Total number of polymer chains | 2 |
Total formula weight | 114720.08 |
Authors | Lindberg, J.,Unge, T. (deposition date: 2001-05-07, release date: 2001-06-06, Last modification date: 2024-02-07) |
Primary citation | Lindberg, J.,Sigurdsson, S.,Lowgren, S.,Andersson, H.O.,Sahlberg, C.,Noreen, R.,Fridborg, K.,Zhang, H.,Unge, T. Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant. Eur.J.Biochem., 269:1670-1677, 2002 Cited by PubMed: 11895437DOI: 10.1046/j.1432-1327.2002.02811.x PDB entries with the same primary citation |
Experimental method |
Structure validation
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