1HXW
HIV-1 PROTEASE DIMER COMPLEXED WITH A-84538
Summary for 1HXW
Entry DOI | 10.2210/pdb1hxw/pdb |
Related PRD ID | PRD_001001 |
Descriptor | HIV-1 PROTEASE, RITONAVIR (3 entities in total) |
Functional Keywords | aspartyl protease, hydrolase, aspartic proteinase, hiv, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P12499 |
Total number of polymer chains | 2 |
Total formula weight | 22382.51 |
Authors | Park, C.H.,Nienaber, V.,Kong, X.P. (deposition date: 1997-01-24, release date: 1998-02-04, Last modification date: 2024-02-07) |
Primary citation | Kempf, D.J.,Marsh, K.C.,Denissen, J.F.,McDonald, E.,Vasavanonda, S.,Flentge, C.A.,Green, B.E.,Fino, L.,Park, C.H.,Kong, X.P. ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans. Proc.Natl.Acad.Sci.USA, 92:2484-2488, 1995 Cited by PubMed: 7708670DOI: 10.1073/pnas.92.7.2484 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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