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1HXB

HIV-1 proteinase complexed with RO 31-8959

Summary for 1HXB
Entry DOI10.2210/pdb1hxb/pdb
Related PRD IDPRD_000454
DescriptorHIV-1 PROTEASE, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide (3 entities in total)
Functional Keywordshydrolase-hydrolase inhibitor complex, aspartyl protease, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus type 1 (CLONE 12)
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585
Total number of polymer chains2
Total formula weight22250.30
Authors
Graves, B.J.,Hatada, M.H.,Crowther, R.L. (deposition date: 1996-09-13, release date: 1997-03-12, Last modification date: 2024-02-07)
Primary citationKrohn, A.,Redshaw, S.,Ritchie, J.C.,Graves, B.J.,Hatada, M.H.
Novel binding mode of highly potent HIV-proteinase inhibitors incorporating the (R)-hydroxyethylamine isostere.
J.Med.Chem., 34:3340-3342, 1991
Cited by
PubMed: 1956054
DOI: 10.1021/jm00115a028
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

217705

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