1HTM

STRUCTURE OF INFLUENZA HAEMAGGLUTININ AT THE PH OF MEMBRANE FUSION

Summary for 1HTM

Entry DOI	10.2210/pdb1htm/pdb
Descriptor	HEMAGGLUTININ HA1 CHAIN, HEMAGGLUTININ HA2 CHAIN (3 entities in total)
Functional Keywords	influenza virus hemagglutinin, viral protein
Biological source	uncultured beta proteobacterium UMTRA-608 More
Cellular location	Virion membrane; Single-pass type I membrane protein (Potential): P03437 P03437
Total number of polymer chains	6
Total formula weight	57132.57
Authors	Bullough, P.A.,Hughson, F.M.,Skehel, J.J.,Wiley, D.C. (deposition date: 1994-11-02, release date: 1995-02-14, Last modification date: 2024-10-30)
Primary citation	Bullough, P.A.,Hughson, F.M.,Skehel, J.J.,Wiley, D.C. Structure of influenza haemagglutinin at the pH of membrane fusion. Nature, 371:37-43, 1994 Cited by PubMed Abstract: Low pH induces a conformational change in the influenza virus haemagglutinin, which then mediates fusion of the viral and host cell membranes. The three-dimensional structure of a fragment of the haemagglutinin in this conformation reveals a major refolding of the secondary and tertiary structure of the molecule. The apolar fusion peptide moves at least 100 A to one tip of the molecule. At the other end a helical segment unfolds, a subdomain relocates reversing the chain direction, and part of the structure becomes disordered. PubMed: 8072525 DOI: 10.1038/371037a0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation