1HKY

Solution structure of a PAN module from Eimeria tenella

Summary for 1HKY

• Entry DOI: 10.2210/pdb1hky/pdb
• Descriptor: MICRONEME PROTEIN 5 PRECURSOR (1 entity in total)
• Functional Keywords: adhesin, pan module, eimeria tenella
• Biological source: EIMERIA TENELLA
• Total number of polymer chains: 1
• Total formula weight: 9233.35

Authors

Brown, P.J.,Mulvey, D.,Potts, J.R.,Tomley, F.M.,Campbell, I.D. (deposition date: 2002-10-03, release date: 2002-10-17, Last modification date: 2024-11-13)

Primary citation

Brown, P.J.,Mulvey, D.,Potts, J.R.,Tomley, F.M.,Campbell, I.D.
Solution Structure of a Pan Module from the Apicomplexan Parasite Eimeria Tenella
J.Struct.Funct.Genom., 4:227-, 2003

PubMed Abstract: Micronemes, specialised organelles found in all apicomplexan parasites, secrete molecules that are essential for parasite attachment and invasion of host cells. EtMIC5 is one such microneme protein that contains eleven tandemly repeating modules. These modules have homology with the PAN module superfamily. Members of this family are found in blood clotting proteins, some growth factors and some nematode proteins. This paper presents the structure of the 9th PAN module in EtMIC5, determined using high resolution NMR. The structure shows similarities to and some differences from the N-terminal module of hepatocyte growth factor (HGF), the only previous member of the PAN family with known structure.

PubMed: 15185963
DOI: 10.1023/B:JSFG.0000016118.87333.03

Experimental method

SOLUTION NMR