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1HJG

Alteration of the co-substrate selectivity of deacetoxycephalosporin C synthase: The role of arginine-258

Summary for 1HJG
Entry DOI10.2210/pdb1hjg/pdb
Related1DCS 1E5H 1E5I 1HJF 1RXF 1RXG
DescriptorDEACETOXYCEPHALOSPORIN C SYNTHASE, FE (II) ION, 3-METHYL-2-OXOBUTANOIC ACID, ... (4 entities in total)
Functional Keywordsoxidoreductase, alternative 2-oxoacids, cephem antibiotic biosynthesis, chemical cosubstrate rescue, co-substrate selectivity, 2- oxoglutarate-dependent oxygenase
Biological sourceSTREPTOMYCES CLAVULIGERUS
Total number of polymer chains1
Total formula weight34734.53
Authors
Lee, H.J.,Lloyd, M.D.,Clifton, I.J.,Harlos, K.,Dubus, A.,Baldwin, J.E.,Frere, J.M.,Schofield, C.J. (deposition date: 2001-01-15, release date: 2001-06-01, Last modification date: 2023-12-13)
Primary citationLee, H.J.,Lloyd, M.D.,Harlos, K.,Clifton, I.J.,Baldwin, J.E.,Schofield, C.J.
Alteration of the 2-Oxoacid Cosubstrate Selectivity in Deacetoxycephalosporin C Synthase: The Role of Arginine-258
J.Biol.Chem., 276:18290-, 2001
Cited by
PubMed: 11279000
DOI: 10.1074/JBC.M100085200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.5 Å)
Structure validation

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