1HIH

COMPARATIVE ANALYSIS OF THE X-RAY STRUCTURES OF HIV-1 AND HIV-2 PROTEASES IN COMPLEX WITH CGP 53820, A NOVEL PSEUDOSYMMETRIC INHIBITOR

Summary for 1HIH

Entry DOI	10.2210/pdb1hih/pdb
Descriptor	HIV-1 PROTEASE, BETA-MERCAPTOETHANOL, ACETYL-NH-VAL-CYCLOHEXYL-CH2[NCH2CHOH]CH2-BENZYL-VAL-NH-ACETYL, ... (4 entities in total)
Functional Keywords	aspartate protease, inhibited, hiv, hydrolase (aspartic proteinase)
Biological source	Human immunodeficiency virus 1
Cellular location	Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366
Total number of polymer chains	2
Total formula weight	22337.54
Authors	Priestle, J.P.,Gruetter, M.G. (deposition date: 1995-03-31, release date: 1995-07-10, Last modification date: 2018-04-18)
Primary citation	Priestle, J.P.,Fassler, A.,Rosel, J.,Tintelnot-Blomley, M.,Strop, P.,Grutter, M.G. Comparative analysis of the X-ray structures of HIV-1 and HIV-2 proteases in complex with CGP 53820, a novel pseudosymmetric inhibitor. Structure, 3:381-389, 1995 Cited by PubMed: 7613867 DOI: 10.1016/S0969-2126(01)00169-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation