1HIH
COMPARATIVE ANALYSIS OF THE X-RAY STRUCTURES OF HIV-1 AND HIV-2 PROTEASES IN COMPLEX WITH CGP 53820, A NOVEL PSEUDOSYMMETRIC INHIBITOR
Summary for 1HIH
Entry DOI | 10.2210/pdb1hih/pdb |
Descriptor | HIV-1 PROTEASE, BETA-MERCAPTOETHANOL, ACETYL-NH-VAL-CYCLOHEXYL-CH2[NCH2CHOH]CH2-BENZYL-VAL-NH-ACETYL, ... (4 entities in total) |
Functional Keywords | aspartate protease, inhibited, hiv, hydrolase (aspartic proteinase) |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 |
Total number of polymer chains | 2 |
Total formula weight | 22337.54 |
Authors | Priestle, J.P.,Gruetter, M.G. (deposition date: 1995-03-31, release date: 1995-07-10, Last modification date: 2018-04-18) |
Primary citation | Priestle, J.P.,Fassler, A.,Rosel, J.,Tintelnot-Blomley, M.,Strop, P.,Grutter, M.G. Comparative analysis of the X-ray structures of HIV-1 and HIV-2 proteases in complex with CGP 53820, a novel pseudosymmetric inhibitor. Structure, 3:381-389, 1995 Cited by PubMed: 7613867DOI: 10.1016/S0969-2126(01)00169-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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