1HA1
HNRNP A1 (RBD1,2) FROM HOMO SAPIENS
Summary for 1HA1
| Entry DOI | 10.2210/pdb1ha1/pdb |
| Descriptor | HNRNP A1 (2 entities in total) |
| Functional Keywords | nuclear protein, hnrnp, rbd, rrm, rnp, rna binding, ribonucleoprotein |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 21052.73 |
| Authors | Shamoo, Y.,Krueger, U.,Rice, L.,Williams, K.R.,Steitz, T.A. (deposition date: 1996-10-30, release date: 1997-05-15, Last modification date: 2024-02-07) |
| Primary citation | Shamoo, Y.,Krueger, U.,Rice, L.M.,Williams, K.R.,Steitz, T.A. Crystal structure of the two RNA binding domains of human hnRNP A1 at 1.75 A resolution. Nat.Struct.Biol., 4:215-222, 1997 Cited by PubMed Abstract: Heterogeneous ribonucleoprotein A1 (hnRNP A1) is an abundant eukaryotic nuclear RNA binding protein. A1 is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm and may modulate splice site selection. The crystal structure of A1(RBD1,2) reveals two independently-folded RNA binding domains (RBDs) connected by a flexible linker. Both RBDs are structurally homologous to the U1A(RBD1), and have their RNA binding platforms oriented in an anti-parallel fashion. The anti-parallel arrangement of the A1 RNA binding platforms suggests mechanisms for RNA condensation and ways of bringing together distant RNA sequences for RNA metabolism such as splicing or transport. PubMed: 9164463DOI: 10.1038/nsb0397-215 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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