1H1B
Crystal structure of human neutrophil elastase complexed with an inhibitor (GW475151)
Summary for 1H1B
Entry DOI | 10.2210/pdb1h1b/pdb |
Related | 1B0F 1HNE 1PPF 1PPG |
Descriptor | LEUKOCYTE ELASTASE, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, (2S)-3-METHYL-2-((2R,3S)-3-[(METHYLSULFONYL)AMINO]-1-{[2-(PYRROLIDIN-1-YLMETHYL)-1,3-OXAZOL-4-YL]CARBONYL}PYRROLIDIN-2-YL)BUTANOIC ACID, ... (4 entities in total) |
Functional Keywords | hydrolase, serine protease |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 2 |
Total formula weight | 48992.42 |
Authors | Macdonald, S.J.F.,Dowle, M.D.,Harrison, L.A.,Clarke, G.D.E.,Inglis, G.G.A.,Johnson, M.R.,Smith, R.A.,Amour, A.,Fleetwood, G.,Humphreys, D.C.,Molloy, C.R.,Dixon, M.,Godward, R.E.,Wonacott, A.J.,Singh, O.M.P.,Hodgson, S.T.,Hardy, G.W. (deposition date: 2002-07-05, release date: 2002-08-29, Last modification date: 2023-12-13) |
Primary citation | Macdonald, S.J.F.,Dowle, M.D.,Harrison, L.A.,Clarke, G.D.E.,Inglis, G.G.A.,Johnson, M.R.,Shah, P.,Smith, R.A.,Amour, A.,Fleetwood, G.,Humphreys, D.C.,Molloy, C.R.,Dixon, M.,Godward, R.E.,Wonacott, A.J.,Singh, O.M.P.,Hodgson, S.T.,Hardy, G.W. Discovery of Further Pyrrolidine Trans-Lactams as Inhibitors of Human Neutrophil Elastase (Hne) with Potential as Development Candidates and the Crystal Structure of Hne Complexed with an Inhibitor (Gw475151) J.Med.Chem., 45:3878-, 2002 Cited by PubMed: 12190311DOI: 10.1021/JM020881F PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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