1GJ6
ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS
Summary for 1GJ6
Entry DOI | 10.2210/pdb1gj6/pdb |
Related | 1C5R |
Descriptor | BETA-TRYPSIN, CALCIUM ION, 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE, ... (4 entities in total) |
Functional Keywords | selectivity at s1, h2o displacement, upa, tpa, ser190/ala190 protease, structure-based drug design, hydrolase |
Biological source | Bos taurus (cattle) |
Cellular location | Secreted, extracellular space: P00760 |
Total number of polymer chains | 1 |
Total formula weight | 23727.20 |
Authors | Katz, B.A.,Sprengeler, P.A.,Luong, C.,Verner, E.,Spencer, J.R.,Breitenbucher, J.G.,Hui, H.,McGee, D.,Allen, D.,Martelli, A.,Mackman, R.L. (deposition date: 2001-04-27, release date: 2002-04-27, Last modification date: 2023-12-27) |
Primary citation | Katz, B.A.,Sprengeler, P.A.,Luong, C.,Verner, E.,Elrod, K.,Kirtley, M.,Janc, J.,Spencer, J.R.,Breitenbucher, J.G.,Hui, H.,McGee, D.,Allen, D.,Martelli, A.,Mackman, R.L. Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets. Chem.Biol., 8:1107-1121, 2001 Cited by PubMed: 11731301DOI: 10.1016/S1074-5521(01)00084-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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