1GFD

SOLUTION STRUCTURE AND LIGAND-BINDING SITE OF THE C-TERMINAL SH3 DOMAIN OF GRB2

Summary for 1GFD

• Entry DOI: 10.2210/pdb1gfd/pdb
• Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 (1 entity in total)
• Functional Keywords: adaptor protein containing sh2 and sh3
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : P62993
• Total number of polymer chains: 1
• Total formula weight: 6785.43

Authors

Kohda, D.,Terasawa, H.,Hatanaka, H.,Inagaki, F. (deposition date: 1994-06-13, release date: 1994-08-31, Last modification date: 2024-05-01)

Primary citation

Kohda, D.,Terasawa, H.,Ichikawa, S.,Ogura, K.,Hatanaka, H.,Mandiyan, V.,Ullrich, A.,Schlessinger, J.,Inagaki, F.
Solution structure and ligand-binding site of the carboxy-terminal SH3 domain of GRB2.
Structure, 2:1029-1040, 1994

PubMed Abstract: Growth factor receptor-bound protein 2 (GRB2) is an adaptor protein with three Src homology (SH) domains in the order SH3-SH2-SH3. Both SH3 domains of GRB2 are necessary for interaction with the protein Son of sevenless (Sos), which acts as a Ras activator. Thus, GRB2 mediates signal transduction from growth factor receptors to Ras and is thought to be a key molecule in signal transduction.

PubMed: 7881903
DOI: 10.1016/S0969-2126(94)00106-5

Experimental method

SOLUTION NMR