1G96

HUMAN CYSTATIN C; DIMERIC FORM WITH 3D DOMAIN SWAPPING

Summary for 1G96

Entry DOI	10.2210/pdb1g96/pdb
Related	1a67 1cew 1dvc 1stf
Descriptor	CYSTATIN C, CHLORIDE ION, GLYCEROL, ... (4 entities in total)
Functional Keywords	human cystatin c dimer, 3d domain swapping, amyloid formation, inhibitor of c1 and c13 cysteine proteases, amyloid angiopathy and cerebral hemorrhage, hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Secreted: P01034
Total number of polymer chains	1
Total formula weight	13492.69
Authors	Janowski, R.,Kozak, M.,Jankowska, E.,Grzonka, Z.,Grubb, A.,Abrahamson, M.,Jaskolski, M. (deposition date: 2000-11-22, release date: 2001-04-06, Last modification date: 2023-08-09)
Primary citation	Janowski, R.,Kozak, M.,Jankowska, E.,Grzonka, Z.,Grubb, A.,Abrahamson, M.,Jaskolski, M. Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swapping. Nat.Struct.Biol., 8:316-320, 2001 Cited by PubMed: 11276250 DOI: 10.1038/86188 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation