1FV0
FIRST STRUCTURAL EVIDENCE OF THE INHIBITION OF PHOSPHOLIPASE A2 BY ARISTOLOCHIC ACID: CRYSTAL STRUCTURE OF A COMPLEX FORMED BETWEEN PHOSPHOLIPASE A2 AND ARISTOLOCHIC ACID
Summary for 1FV0
Entry DOI | 10.2210/pdb1fv0/pdb |
Related | 1CL5 1FE7 |
Descriptor | PHOSPHOLIPASE A2, SULFATE ION, ACETATE ION, ... (7 entities in total) |
Functional Keywords | phospholipase a2, daboia russelli pulchella, neurotoxic, edema, toxin |
Biological source | Daboia russellii pulchella |
Cellular location | Secreted : P59071 |
Total number of polymer chains | 2 |
Total formula weight | 28420.50 |
Authors | Chandra, V.,Jasti, J.,Kaur, P.,Srinivasan, A.,Betzel, C.,Singh, T.P. (deposition date: 2000-09-18, release date: 2002-08-28, Last modification date: 2023-08-09) |
Primary citation | Chandra, V.,Jasti, J.,Kaur, P.,Srinivasan, A.,Betzel, C.,Singh, T.P. Structural Basis of Phospholipase A2 Inhibition for the Synthesis of Prostaglandins by the Plant Alkaloid Aristolochic Acid from a 1.7 A Crystal Structure Biochemistry, 41:10914-10919, 2002 Cited by PubMed: 12206661DOI: 10.1021/bi0258593 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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