1FT4
PHOTOCHEMICALLY-ENHANCED BINDING OF SMALL MOLECULES TO THE TUMOR NECROSIS FACTOR RECEPTOR-1
Summary for 1FT4
Entry DOI | 10.2210/pdb1ft4/pdb |
Related | 1NCF |
Descriptor | SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR 1, 5-(3-MORPHOLIN-4-YL-PROPYL)-2-(3-NITRO-PHENYL)-4-THIOXO-4,5-DIHYDRO-1-THIA-3B,5-DIAZA-CYCLOPENTA[A]PENTALEN-6-ONE (2 entities in total) |
Functional Keywords | binding protein, cytokine, signaling protein |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane ; Single-pass type I membrane protein . Isoform 4: Secreted: P19438 |
Total number of polymer chains | 2 |
Total formula weight | 37128.20 |
Authors | Muckelbauer, J.K.,Chang, C.-H. (deposition date: 2000-09-11, release date: 2001-10-12, Last modification date: 2017-10-04) |
Primary citation | Carter, P.H.,Scherle, P.A.,Muckelbauer, J.K.,Voss, M.E.,Liu, R.Q.,Thompson, L.A.,Tebben, A.J.,Solomon, K.A.,Lo, Y.C.,Li, Z.,Strzemienski, P.,Yang, G.,Falahatpisheh, N.,Xu, M.,Wu, Z.,Farrow, N.A.,Ramnarayan, K.,Wang, J.,Rideout, D.,Yalamoori, V.,Domaille, P.,Underwood, D.J.,Trzaskos, J.M.,Friedman, S.M.,Newton, R.C.,Decicco, C.P.,Muckelbauer, J.A. Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-alpha. Proc.Natl.Acad.Sci.USA, 98:11879-11884, 2001 Cited by PubMed: 11592999DOI: 10.1073/pnas.211178398 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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