1FJ5
TAMOXIFEN-DNA ADDUCT
Summary for 1FJ5
Entry DOI | 10.2210/pdb1fj5/pdb |
Descriptor | DNA (5'-D(*CP*CP*AP*TP*CP*GP*CP*TP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*AP*GP*CP*GP*AP*TP*GP*G)-3'), (Z)-2-[4-(1,2)-DIPHENYL-1-BUTENYL)-PHENOXY]-N,N-DIMETHYLETHANAMINIUM (3 entities in total) |
Functional Keywords | covalent dna-tamoxifen complex; groove binding; localized helical perturbation; widened minor groove, dna |
Total number of polymer chains | 2 |
Total formula weight | 7080.92 |
Authors | Shimotakahara, S.,Gorin, A.,Kolbanovskiy, A.,Kettani, A.,Hingerty, B.E.,Amin, S.,Broyde, S.,Geacintov, N.,Patel, D.J. (deposition date: 2000-08-07, release date: 2000-09-11, Last modification date: 2024-05-22) |
Primary citation | Shimotakahara, S.,Gorin, A.,Kolbanovskiy, A.,Kettani, A.,Hingerty, B.E.,Amin, S.,Broyde, S.,Geacintov, N.,Patel, D.J. Accomodation of S-cis-tamoxifen-N(2)-guanine adduct within a bent and widened DNA minor groove. J.Mol.Biol., 302:377-393, 2000 Cited by PubMed: 10970740DOI: 10.1006/jmbi.2000.4071 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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