1EAU
NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 6. DESIGN OF A POTENT, INTRATRACHEALLY ACTIVE, PYRIDONE-BASED TRIFLUOROMETHYL KETONE
Summary for 1EAU
Entry DOI | 10.2210/pdb1eau/pdb |
Descriptor | PORCINE PANCREATIC ELASTASE, SODIUM ION, SULFATE ION, ... (5 entities in total) |
Functional Keywords | hydrolase (serine protease) |
Biological source | Sus scrofa (pig) |
Cellular location | Secreted: P00772 |
Total number of polymer chains | 1 |
Total formula weight | 26587.67 |
Authors | Ceccarelli, C. (deposition date: 1994-11-22, release date: 1995-02-07, Last modification date: 2024-06-05) |
Primary citation | Bernstein, P.R.,Gomes, B.C.,Kosmider, B.J.,Vacek, E.P.,Williams, J.C. Nonpeptidic inhibitors of human leukocyte elastase. 6. Design of a potent, intratracheally active, pyridone-based trifluoromethyl ketone. J.Med.Chem., 38:212-215, 1995 Cited by PubMed: 7837235DOI: 10.1021/jm00001a028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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