1DB4
HUMAN S-PLA2 IN COMPLEX WITH INDOLE 8
Summary for 1DB4
Entry DOI | 10.2210/pdb1db4/pdb |
Related | 1DB5 1DCY |
Descriptor | PHOSPHOLIPASE A2, CALCIUM ION, [3-(1-BENZYL-3-CARBAMOYLMETHYL-2-METHYL-1H-INDOL-5-YLOXY)-PROPYL-]-PHOSPHONIC ACID, ... (4 entities in total) |
Functional Keywords | s-pla2, structure-based drug design, hydrolase/hydrolase inhibitor, hydrolase-hydrolase inhibitor complex |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Peripheral membrane protein: P14555 |
Total number of polymer chains | 1 |
Total formula weight | 14441.58 |
Authors | Chirgadze, N.Y.,Schevitz, R.W.,Wery, J.-P. (deposition date: 1999-11-02, release date: 1999-11-12, Last modification date: 2011-07-13) |
Primary citation | Schevitz, R.W.,Bach, N.J.,Carlson, D.G.,Chirgadze, N.Y.,Clawson, D.K.,Dillard, R.D.,Draheim, S.E.,Hartley, L.W.,Jones, N.D.,Mihelich, E.D.,Olkowski, J.L.,Snyder, D.W.,Sommers, C.,Wery, J.-P. Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2. Nat.Struct.Biol., 2:458-465, 1995 Cited by PubMed: 7664108DOI: 10.1038/nsb0695-458 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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