1D8B

NMR STRUCTURE OF THE HRDC DOMAIN FROM SACCHAROMYCES CEREVISIAE RECQ HELICASE

Summary for 1D8B

Entry DOI	10.2210/pdb1d8b/pdb
NMR Information	BMRB: 4445
Descriptor	SGS1 RECQ HELICASE (1 entity in total)
Functional Keywords	five helices, three-helical bundle flanked by two helices, dna binding protein
Biological source	Saccharomyces cerevisiae (baker's yeast)
Cellular location	Nucleus, nucleolus: P35187
Total number of polymer chains	1
Total formula weight	9385.96
Authors	Liu, Z.,Macias, M.J.,Bottomley, M.J.,Stier, G.,Linge, J.P.,Nilges, M.,Bork, P.,Sattler, M. (deposition date: 1999-10-21, release date: 2000-01-10, Last modification date: 2024-05-22)
Primary citation	Liu, Z.,Macias, M.J.,Bottomley, M.J.,Stier, G.,Linge, J.P.,Nilges, M.,Bork, P.,Sattler, M. The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins. Structure Fold.Des., 7:1557-1566, 1999 Cited by PubMed Abstract: The HRDC (helicase and RNaseD C-terminal) domain is found at the C terminus of many RecQ helicases, including the human Werner and Bloom syndrome proteins. RecQ helicases have been shown to unwind DNA in an ATP-dependent manner. However, the specific functional roles of these proteins in DNA recombination and replication are not known. An HRDC domain exists in both of the human RecQ homologues that are implicated in human disease and may have an important role in their function. PubMed: 10647186 DOI: 10.1016/S0969-2126(00)88346-X PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation