1BZG
THE SOLUTION STRUCTURE OF HUMAN PARATHYROID HORMONE-RELATED PROTEIN (1-34) IN NEAR-PHYSIOLOGICAL SOLUTION, NMR, 30 STRUCTURES
Summary for 1BZG
| Entry DOI | 10.2210/pdb1bzg/pdb |
| Descriptor | PARATHYROID HORMONE-RELATED PROTEIN (1 entity in total) |
| Functional Keywords | human peptide hormone, stimulating intracellular camp formation, serum calcium level, humoral hypercalcemia of malignancy, solution structure, pthrp, pth, hormone |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 4027.64 |
| Authors | Weidler, M.,Marx, U.C.,Seidel, G.,Roesch, P. (deposition date: 1998-10-28, release date: 1999-05-18, Last modification date: 2024-05-22) |
| Primary citation | Weidler, M.,Marx, U.C.,Seidel, G.,Schafer, W.,Hoffmann, E.,Esswein, A.,Rosch, P. The structure of human parathyroid hormone-related protein(1-34) in near-physiological solution. FEBS Lett., 444:239-244, 1999 Cited by PubMed Abstract: Parathyroid hormone-related protein plays a major role in the pathogenesis of humoral hypercalcemia of malignancy. Under normal physiological conditions, parathyroid hormone-related protein is produced in a wide variety of tissues and acts in an autocrine or paracrine fashion. Parathyroid hormone-related protein and parathyroid hormone bind to and activate the same G-protein-coupled receptor. Here we present the structure of the biologically active NH2-terminal domain of human parathyroid hormone-related protein(1-34) in near-physiological solution in the absence of crowding reagents as determined by two-dimensional proton magnetic resonance spectroscopy. An improved strategy for structure calculation revealed the presence of two helices, His-5-Leu-8 and Gln-16-Leu-27, connected by a flexible linker. The parathyroid hormone-related protein(1-34) structure and the structure of human parathyroid hormone(1-37) as well as human parathyroid hormone(1-34) are highly similar, except for the well defined turn, His-14-Ser-17, present in parathyroid hormone. Thus, the similarity of the binding affinities of parathyroid hormone and parathyroid hormone-related protein to their common receptor may be based on their structural similarity. PubMed: 10050767DOI: 10.1016/S0014-5793(98)01658-5 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
Download full validation report
