1BVG

HIV-1 PROTEASE-DMP323 COMPLEX IN SOLUTION, NMR MINIMIZED AVERAGE STRUCTURE

Summary for 1BVG

• Entry DOI: 10.2210/pdb1bvg/pdb
• Related: 1BVE
• Descriptor: HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHEN YLMETHYL)]-2H-1,3-DIAZEPINONE (2 entities in total)
• Functional Keywords: aids, polyprotein, hydrolase, aspartyl protease, endonuclease, rna-directed dna polymerase
• Biological source: Human immunodeficiency virus 1
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585
• Total number of polymer chains: 2
• Total formula weight: 22082.02

Authors

Yamazaki, T.,Hinck, A.P.,Wang, Y.-X.,Nicholson, L.K.,Torchia, D.A.,Wingfield, P.,Stahl, S.J.,Kaufman, J.D.,Chang, C.,Domaille, P.J.,Lam, P.Y.S. (deposition date: 1996-01-16, release date: 1996-08-17, Last modification date: 2021-11-03)

• Primary citation: Yamazaki, T.,Hinck, A.P.,Wang, Y.X.,Nicholson, L.K.,Torchia, D.A.,Wingfield, P.,Stahl, S.J.,Kaufman, J.D.,Chang, C.H.,Domaille, P.J.,Lam, P.Y.; Three-dimensional solution structure of the HIV-1 protease complexed with DMP323, a novel cyclic urea-type inhibitor, determined by nuclear magnetic resonance spectroscopy.; Protein Sci., 5:495-506, 1996; PubMed: 8868486

Experimental method

SOLUTION NMR