1B08

LUNG SURFACTANT PROTEIN D (SP-D) (FRAGMENT)

Summary for 1B08

• Entry DOI: 10.2210/pdb1b08/pdb
• Descriptor: PROTEIN (LUNG SURFACTANT PROTEIN D), CALCIUM ION (3 entities in total)
• Functional Keywords: c-type lectin, crd, sp-d, colectin, alpha-helical coiled-coil, lung surfactant, sugar binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 51528.42

Authors

Hakansson, K.,Lim, N.K.,Hoppe, H.-J.,Reid, K.B.M. (deposition date: 1998-11-18, release date: 1999-12-01, Last modification date: 2024-11-06)

Primary citation

Hakansson, K.,Lim, N.K.,Hoppe, H.J.,Reid, K.B.
Crystal structure of the trimeric alpha-helical coiled-coil and the three lectin domains of human lung surfactant protein D.
Structure Fold.Des., 7:255-264, 1999

PubMed Abstract: Human lung surfactant protein D (hSP-D) belongs to the collectin family of C-type lectins and participates in the innate immune surveillance against microorganisms in the lung through recognition of carbohydrate ligands present on the surface of pathogens. The involvement of this protein in innate immunity and the allergic response make it the subject of much interest.

PubMed: 10368295
DOI: 10.1016/S0969-2126(99)80036-7

Experimental method

X-RAY DIFFRACTION (2.3 Å)