1AU4
CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PYRROLIDINONE INHIBITOR
Summary for 1AU4
Entry DOI | 10.2210/pdb1au4/pdb |
Descriptor | CATHEPSIN K, 4-[[N-[(PHENYLMETHOXY)CARBONYL]-/NL/N-LEUCYL]AMINO]-1[(2S)-2-[[[4-(PYRIDINYLMETHOXY)CARBONYL]AMINO]-4-METHYLPENT/NYL]-3-PYRROLIDINONE/N (3 entities in total) |
Functional Keywords | hydrolase, sulfhydryl proteinase |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: P43235 |
Total number of polymer chains | 1 |
Total formula weight | 24105.18 |
Authors | Zhao, B.,Smith, W.W.,Janson, C.A.,Abdel-Meguid, S.S. (deposition date: 1997-09-10, release date: 1998-10-14, Last modification date: 2023-08-02) |
Primary citation | Marquis, R.W.,Yamashita, D.S.,Ru, Y.,LoCastro, S.M.,Oh, H.J.,Erhard, K.F.,DesJarlais, R.L.,Head, M.S.,Smith, W.W.,Zhao, B.,Janson, C.A.,Abdel-Meguid, S.S.,Tomaszek, T.A.,Levy, M.A.,Veber, D.F. Conformationally constrained 1,3-diamino ketones: a series of potent inhibitors of the cysteine protease cathepsin K. J.Med.Chem., 41:3563-3567, 1998 Cited by PubMed: 9733481DOI: 10.1021/jm980295f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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