1AJ6

NOVOBIOCIN-RESISTANT MUTANT (R136H) OF THE N-TERMINAL 24 KDA FRAGMENT OF DNA GYRASE B COMPLEXED WITH NOVOBIOCIN AT 2.3 ANGSTROMS RESOLUTION

Summary for 1AJ6

Entry DOI	10.2210/pdb1aj6/pdb
Descriptor	GYRASE, NOVOBIOCIN (3 entities in total)
Functional Keywords	topoisomerase, gyrase, novobiocin, antibiotic, resistant mutant
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	24653.56
Authors	Weston, S.A.,Tunnicliffe, A.,Pauptit, R.A. (deposition date: 1997-05-15, release date: 1998-05-20, Last modification date: 2024-04-03)
Primary citation	Holdgate, G.A.,Tunnicliffe, A.,Ward, W.H.,Weston, S.A.,Rosenbrock, G.,Barth, P.T.,Taylor, I.W.,Pauptit, R.A.,Timms, D. The entropic penalty of ordered water accounts for weaker binding of the antibiotic novobiocin to a resistant mutant of DNA gyrase: a thermodynamic and crystallographic study. Biochemistry, 36:9663-9673, 1997 Cited by PubMed: 9245398 DOI: 10.1021/bi970294+ PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation