1AID
STRUCTURE OF A NON-PEPTIDE INHIBITOR COMPLEXED WITH HIV-1 PROTEASE: DEVELOPING A CYCLE OF STRUCTURE-BASED DRUG DESIGN
Summary for 1AID
Entry DOI | 10.2210/pdb1aid/pdb |
Descriptor | HUMAN IMMUNODEFICIENCY VIRUS PROTEASE, CHLORIDE ION, 4-(4-CHLORO-PHENYL)-1-{3-[2-(4-FLUORO-PHENYL)-[1,3]DITHIOLAN-2-YL]-PROPYL}-PIPERIDIN-4-OL, ... (4 entities in total) |
Functional Keywords | hydrolase, protease, hiv, non-peptide inhibitor, drug design |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03369 |
Total number of polymer chains | 2 |
Total formula weight | 22088.92 |
Authors | Rutenber, E.E.,Fauman, E.B.,Keenan, R.J.,Stroud, R.M. (deposition date: 1997-04-16, release date: 1997-10-15, Last modification date: 2024-05-22) |
Primary citation | Rutenber, E.,Fauman, E.B.,Keenan, R.J.,Fong, S.,Furth, P.S.,Ortiz de Montellano, P.R.,Meng, E.,Kuntz, I.D.,DeCamp, D.L.,Salto, R.,Rosb, J.R.,Craik, C.S.,Stroud, R.M. Structure of a non-peptide inhibitor complexed with HIV-1 protease. Developing a cycle of structure-based drug design. J.Biol.Chem., 268:15343-15346, 1993 Cited by PubMed: 8340363PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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