1A9M
G48H MUTANT OF HIV-1 PROTEASE IN COMPLEX WITH A PEPTIDIC INHIBITOR U-89360E
Summary for 1A9M
| Entry DOI | 10.2210/pdb1a9m/pdb |
| Descriptor | HIV-1 PROTEASE, N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE (3 entities in total) |
| Functional Keywords | aspartyl protease, drug resistant, mutation |
| Biological source | Human immunodeficiency virus 1 |
| Total number of polymer chains | 2 |
| Total formula weight | 22366.47 |
| Authors | Hong, L.,Zhang, X.-J.,Foundling, S.,Hartsuck, J.A.,Tang, J. (deposition date: 1998-04-08, release date: 1998-06-17, Last modification date: 2023-08-02) |
| Primary citation | Hong, L.,Zhang, X.J.,Foundling, S.,Hartsuck, J.A.,Tang, J. Structure of a G48H mutant of HIV-1 protease explains how glycine-48 replacements produce mutants resistant to inhibitor drugs. FEBS Lett., 420:11-16, 1997 Cited by PubMed: 9450540DOI: 10.1016/S0014-5793(97)01477-4 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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