1A42

HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH BRINZOLAMIDE

Summary for 1A42

Entry DOI	10.2210/pdb1a42/pdb
Descriptor	CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION, ... (5 entities in total)
Functional Keywords	lyase, zinc, inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00918
Total number of polymer chains	1
Total formula weight	29807.37
Authors	Boriack-Sjodin, P.A.,Christianson, D.W. (deposition date: 1998-02-10, release date: 1999-03-23, Last modification date: 2024-04-03)
Primary citation	Stams, T.,Chen, Y.,Boriack-Sjodin, P.A.,Hurt, J.D.,Liao, J.,May, J.A.,Dean, T.,Laipis, P.,Silverman, D.N.,Christianson, D.W. Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination. Protein Sci., 7:556-563, 1998 Cited by PubMed: 9541386 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation