184D

SELF-ASSOCIATION OF A DNA LOOP CREATES A QUADRUPLEX: CRYSTAL STRUCTURE OF D(GCATGCT) AT 1.8 ANGSTROMS RESOLUTION

Summary for 184D

• Entry DOI: 10.2210/pdb184d/pdb
• Descriptor: DNA (5'-D(*GP*CP*AP*TP*GP*CP*T)-3'), MAGNESIUM ION (3 entities in total)
• Functional Keywords: u-dna, quadruple helix, tetraplex, loop, dna
• Total number of polymer chains: 1
• Total formula weight: 2162.02

Authors

Leonard, G.A.,Zhang, S.,Peterson, M.R.,Harrop, S.J.,Helliwell, J.R.,Cruse, W.B.T.,Langlois D'Estaintot, B.,Kennard, O.,Brown, T.,Hunter, W.N. (deposition date: 1994-08-10, release date: 1995-07-10, Last modification date: 2024-02-07)

Primary citation

Leonard, G.A.,Zhang, S.,Peterson, M.R.,Harrop, S.J.,Helliwell, J.R.,Cruse, W.B.,d'Estaintot, B.L.,Kennard, O.,Brown, T.,Hunter, W.N.
Self-association of a DNA loop creates a quadruplex: crystal structure of d(GCATGCT) at 1.8 A resolution.
Structure, 3:335-340, 1995

PubMed Abstract: The flexibility of DNA enables it to adopt three interconvertible types of duplex termed the A-, B- and Z-forms. It can also produce hairpin loops, triplex structures and guanine-rich quadruplex structures. Conformational flexibility assists in the tight packaging of DNA, for example in chromosomes. This is important given the large quantity of genetic information that must be packaged efficiently. Moreover, the ability of DNA to specifically self-associate or interact with complementary sequences is fundamental to many biological processes. Structural studies provide information about DNA conformation and DNA-DNA interactions and suggest features that might be relevant to how the molecule performs its biological role.

PubMed: 7613864
DOI: 10.1016/S0969-2126(01)00165-4

Experimental method

X-RAY DIFFRACTION (1.8 Å)