184D

SELF-ASSOCIATION OF A DNA LOOP CREATES A QUADRUPLEX: CRYSTAL STRUCTURE OF D(GCATGCT) AT 1.8 ANGSTROMS RESOLUTION

184D の概要

• エントリーDOI: 10.2210/pdb184d/pdb
• 分子名称: DNA (5'-D(*GP*CP*AP*TP*GP*CP*T)-3'), MAGNESIUM ION (3 entities in total)
• 機能のキーワード: u-dna, quadruple helix, tetraplex, loop, dna
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 2162.02

構造登録者

Leonard, G.A.,Zhang, S.,Peterson, M.R.,Harrop, S.J.,Helliwell, J.R.,Cruse, W.B.T.,Langlois D'Estaintot, B.,Kennard, O.,Brown, T.,Hunter, W.N. (登録日: 1994-08-10, 公開日: 1995-07-10, 最終更新日: 2024-02-07)

主引用文献

Leonard, G.A.,Zhang, S.,Peterson, M.R.,Harrop, S.J.,Helliwell, J.R.,Cruse, W.B.,d'Estaintot, B.L.,Kennard, O.,Brown, T.,Hunter, W.N.
Self-association of a DNA loop creates a quadruplex: crystal structure of d(GCATGCT) at 1.8 A resolution.
Structure, 3:335-340, 1995

PubMed Abstract: The flexibility of DNA enables it to adopt three interconvertible types of duplex termed the A-, B- and Z-forms. It can also produce hairpin loops, triplex structures and guanine-rich quadruplex structures. Conformational flexibility assists in the tight packaging of DNA, for example in chromosomes. This is important given the large quantity of genetic information that must be packaged efficiently. Moreover, the ability of DNA to specifically self-associate or interact with complementary sequences is fundamental to many biological processes. Structural studies provide information about DNA conformation and DNA-DNA interactions and suggest features that might be relevant to how the molecule performs its biological role.

PubMed: 7613864
DOI: 10.1016/S0969-2126(01)00165-4

実験手法

X-RAY DIFFRACTION (1.8 Å)