168D

STABILIZING EFFECTS OF THE RNA 2'-SUBSTITUENT: CRYSTAL STRUCTURE OF AN OLIGODEOXYNUCLEOTIDE DUPLEX CONTAINING 2'-O-METHYLATED ADENOSINES

168D の概要

• エントリーDOI: 10.2210/pdb168d/pdb
• 分子名称: DNA/RNA (5'-D(*GP*CP*GP*TP*)-R(*(A2M)P*)-D(*TP*AP*CP*GP*C)-3') (2 entities in total)
• 機能のキーワード: a-dna/rna, double helix, modified, dna-rna hybrid complex, dna-rna hybrid
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 6150.06

構造登録者

Lubini, P.,Zuercher, W.,Egli, M. (登録日: 1994-04-08, 公開日: 1994-08-31, 最終更新日: 2024-02-07)

主引用文献

Lubini, P.,Zurcher, W.,Egli, M.
Stabilizing effects of the RNA 2'-substituent: crystal structure of an oligodeoxynucleotide duplex containing 2'-O-methylated adenosines.
Chem.Biol., 1:39-45, 1994

PubMed Abstract: The stability of hybrids of 2'-O-methyl-ribonucleotides with complementary RNA is considerably higher than that of the corresponding DNA.RNA duplexes. The 2'-O-modified ribonucleotides are thus an attractive class of compounds for antisense applications. Understanding how these substituents stabilize the structure of the hybrid duplex may be important in the design of ribonucleotides with novel properties.

PubMed: 9383369
DOI: 10.1016/1074-5521(94)90039-6

実験手法

X-RAY DIFFRACTION (2 Å)