156D

REFINED SOLUTION STRUCTURE OF THE DIMERIC QUADRUPLEX FORMED FROM THE OXYTRICHA TELOMERIC OLIGONUCLEOTIDE D(GGGGTTTTGGGG)

156D の概要

• エントリーDOI: 10.2210/pdb156d/pdb
• 分子名称: DNA (5'-D(*GP*GP*GP*GP*TP*TP*TP*TP*GP*GP*GP*G)-3') (1 entity in total)
• 機能のキーワード: dna, quadruplex, oxytricha telomeric oligonucleotide d(ggggttttgggg)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7610.92

構造登録者

Schultze, P.,Smith, F.W.,Feigon, J. (登録日: 1994-01-17, 公開日: 1994-04-30, 最終更新日: 2024-05-22)

主引用文献

Schultze, P.,Smith, F.W.,Feigon, J.
Refined solution structure of the dimeric quadruplex formed from the Oxytricha telomeric oligonucleotide d(GGGGTTTTGGGG).
Structure, 2:221-233, 1994

PubMed Abstract: Telomeres, the structures at the ends of linear eukaryotic chromosomes, are essential for chromosome replication and stability. The telomeres of the unicellular ciliate Oxytricha contain a 3' single strand overhang composed of two repeats of the telomere repeat sequence d(TTTTGGGG). It has been proposed that oligonucleotides containing this repeat can form DNA quadruplexes via hydrogen bonding of the guanines into quartets. Such structures may be relevant to the biological function of the telomere, and in G-rich sequences elsewhere in the genome.

PubMed: 8069635
DOI: 10.1016/S0969-2126(00)00023-X

実験手法

SOLUTION NMR