11AK

Cryo-EM structure of a bovine CLC-K S68N/R355K chloride channel with inhibitor M-BIM15

This is a non-PDB format compatible entry.

Summary for 11AK

• Entry DOI: 10.2210/pdb11ak/pdb
• Related: 11EV
• EMDB information: 75588
• Descriptor: Chloride voltage-gated channel Ka, (1M)-6-chloro-1-(3-chloro[1,1'-biphenyl]-4-yl)-1H-1,3-benzimidazole-2-sulfonic acid, CHLORIDE ION (3 entities in total)
• Functional Keywords: chloride channel, membrane protein, transport protein
• Biological source: Bos taurus (domestic cattle)
• Total number of polymer chains: 2
• Total formula weight: 148021.36

Authors

Chien, C.-T.,Chiu, W.,Maduke, M. (deposition date: 2026-02-13, release date: 2026-09-09)

• Primary citation: Chien, C.T.,Sobecks-Doherty, B.L.,Powers, A.S.,Das, A.,Kreiter, J.,Barry, C.N.,Chen, M.,Hinman, A.,Petrakian, C.F.,Williams, B.,Wood, C.A.P.,Xu, M.,Dror, R.O.,Chiu, W.,Maduke, M.; Mechanism of gating and isoform-specific inhibition in renal CLC chloride channels; Proc.Natl.Acad.Sci.USA, 123:-, 2026; DOI: 10.1073/pnas.2605886123

Experimental method

ELECTRON MICROSCOPY (3 Å)