10GF

The eukaryotic translation initiation factor 2B from Homo sapiens with a L179V mutation in the delta subunit, I-state

Summary for 10GF

Entry DOI	10.2210/pdb10gf/pdb
EMDB information	75149
Descriptor	Translation initiation factor eIF-2B subunit epsilon, Translation initiation factor eIF2B subunit delta, Translation initiation factor eIF2B subunit alpha, ... (7 entities in total)
Functional Keywords	complex, gef, translation, guanine nucleotide exchange factor
Biological source	Homo sapiens (human) More
Total number of polymer chains	10
Total formula weight	530666.49
Authors	Dalwadi, U.,Boone, M.,Croll, T.I.,Laughlin, T.G.,Frost, A.,Walter, P. (deposition date: 2026-01-19, release date: 2026-10-28)
Primary citation	Boone, M.,Dalwadi, U.,Deal, A.,Zhu, P.J.,Croll, T.I.,Yamazaki, M.,Prescott, K.,Minopoli, R.,Biscocho, I.,Wang, J.,Lee, D.J.,Arthur, C.P.,Laughlin, T.G.,Zhou, H.,Klope, M.T.,Egea, P.F.,Schoof, M.,Lawrence, R.,Renslo, A.R.,Costa-Mattioli, M.,Frost, A.,Walter, P. Stereoselective methyl-swapping demonstrates target specificity of cognitive enhancer Biorxiv, 2026 Cited by DOI: 10.64898/2026.02.04.700910 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.5 Å)

Structure validation