6DFN
Crystal structure of estrogen receptor alpha in complex with receptor degrader 16aa
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Estrogen receptor | polymer | 280 | 31980.3 | 4 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
2 | A, B, C, D | (2S)-3-(3-hydroxyphenyl)-2-(4-iodophenyl)-4-methyl-2H-1-benzopyran-6-ol | non-polymer | 456.3 | 4 | Chemie (G9J) | |||
3 | A | NICKEL (II) ION | non-polymer | 58.7 | 1 | Chemie (NI) | |||
4 | B, D | (8S)-8-(4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-1,8-dihydro-2H-[1]benzopyrano[4,3-d][1]benzoxepine-5,11-diol | non-polymer | 489.5 | 2 | Chemie (G91) | |||
5 | B, D | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
6 | water | water | 18.0 | 45 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 298 - 553 (UniProt: P03372)
PDB | External Database | Details |
---|---|---|
Met 274 | - | initiating methionine |
His 275 | - | expression tag |
His 276 | - | expression tag |
His 277 | - | expression tag |
His 278 | - | expression tag |
His 279 | - | expression tag |
His 280 | - | expression tag |
Ser 281 | - | expression tag |
Ser 282 | - | expression tag |
Gly 283 | - | expression tag |
Val 284 | - | expression tag |
Asp 285 | - | expression tag |
Leu 286 | - | expression tag |
Gly 287 | - | expression tag |
Thr 288 | - | expression tag |
Glu 289 | - | expression tag |
Asn 290 | - | expression tag |
Leu 291 | - | expression tag |
Tyr 292 | - | expression tag |
Phe 293 | - | expression tag |
Gln 294 | - | expression tag |
Ser 295 | - | expression tag |
Asn 296 | - | expression tag |
Ala 297 | - | expression tag |
Ser 372 | Leu 372 | conflict |
Ser 536 | Leu 536 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 127921.2 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 3139.1 | |
All* | Total formula weight | 131060.3 |