6CDE

Cryo-EM structure at 3.8 A resolution of vaccine-elicited antibody vFP20.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122

これはPDB形式変換不可エントリーです。

エンティティ

Entity ID	鎖名	説明	種類	鎖長	化学式量	分子数	データベース名(アクセス番号)	由来する生物種	エンティティの一般名
1	h, H, 3	vFP20.01 Heavy Chain	polymer	211	22673.6	3		Homo sapiens (human)
2	l, L, 4	vFP20.01 Light chain	polymer	216	23826.7	3		Homo sapiens (human)
3	M, m, 7	PGT122 Heavy chain	polymer	228	24710.8	3		Homo sapiens (human)
4	N, n, 8	PGT122 Light Chain	polymer	210	22560.9	3		Homo sapiens (human)
5	R, r, 6	VRC03 Light Chain	polymer	208	23043.7	3		Homo sapiens (human)
6	Q, q, 5	VRC03 Heavy Chain	polymer	227	24653.8	3		Homo sapiens (human)
7	D, d, 1	Glycoprotein 41	polymer	153	17162.5	3	UniProt (Q2N0S7) Pfam (PF00517) In PDB	Human immunodeficiency virus 1
8	C, c, 2	Glycoprotein 120	polymer	473	52987.0	3	UniProt (Q2N0S5) Pfam (PF00516) In PDB	Human immunodeficiency virus 1
9	s, u, w, x, y...	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	18	In PDB GlyTouCan (G15407YE)
10	E, F, K, S, 0...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	12	In PDB GlyTouCan (G42666HT)
11	G, AA, f	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	3	In PDB GlyTouCan (G81315DD)
12	I, BA, g	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1073.0	3	In PDB GlyTouCan (G56014GC)
13	J, CA, i	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1397.2	3	In PDB GlyTouCan (G83582BK)
14	O, EA, k	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	3	In PDB GlyTouCan (G22768VO)
15	P, FA, o	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1397.2	3	In PDB GlyTouCan (G33303XH)
16	t, U, IA	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1559.4	3	In PDB GlyTouCan (G63337SS)
17	v, W, KA	alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	3	In PDB GlyTouCan (G22573RC)
18	C, d, c, 1, 2...	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	9	Chemie (NAG)
19	c, 2, C	alpha-D-mannopyranose	non-polymer		180.2	3	Chemie (MAN)

配列変更

D, d, 1: 512 - 664 (UniProt: Q2N0S7)

PDB	外部データベース	詳細
Cys 605	Thr 602	conflict

C, c, 2: 31 - 505 (UniProt: Q2N0S5)

PDB	外部データベース	詳細
Cys 201	Ile 200	conflict
Asn 332	Thr 330	conflict
Cys 433	Ala 430	conflict
Cys 501	Ala 498	conflict

非対称単位の内容

タンパク質・ 核酸鎖	鎖の数	24
	化学式量合計	634856.9
糖鎖	分子数	51
	化学式量合計	39155.6
タンパク質・ 核酸・ 糖鎖以外*	分子数	12
	化学式量合計	2531.3
全て*	化学式量合計	676543.9

*水分子は含んでいません