6C9H
non-phosphorylated AMP-activated protein kinase bound to pharmacological activator R734
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | polymer | 494 | 57165.6 | 1 | UniProt (Q13131) Pfam (PF00069) Pfam (PF21147) Pfam (PF16579) In PDB | Homo sapiens (Human) | AMPK subunit alpha-1,Acetyl-CoA carboxylase kinase,ACACA kinase,Hydroxymethylglutaryl-CoA reductase kinase,HMGCR kinase,Tau-protein kinase PRKAA1 |
2 | B | 5'-AMP-activated protein kinase subunit beta-1 | polymer | 204 | 23071.3 | 1 | UniProt (Q9Y478) Pfam (PF16561) Pfam (PF04739) In PDB | Homo sapiens (Human) | AMPKb |
3 | C | 5'-AMP-activated protein kinase subunit gamma-1 | polymer | 331 | 37626.3 | 1 | UniProt (P54619) Pfam (PF00571) In PDB | Homo sapiens (Human) | AMPKg |
4 | A | 5-{[6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzimidazol-2-yl]oxy}-N-hydroxy-2-methylbenzamide | non-polymer | 446.9 | 1 | Chemie (R34) | |||
5 | A | STAUROSPORINE | non-polymer | 466.5 | 1 | Chemie (STU) | |||
6 | C | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 3 | Chemie (AMP) | |||
7 | water | water | 18.0 | 80 | Chemie (HOH) |
Sequence modifications
A: 13 - 471 (UniProt: Q13131)
A: 526 - 550 (UniProt: Q13131)
B: 68 - 270 (UniProt: Q9Y478)
PDB | External Database | Details |
---|---|---|
Met 3 | - | expression tag |
Gly 4 | - | expression tag |
His 5 | - | expression tag |
His 6 | - | expression tag |
His 7 | - | expression tag |
His 8 | - | expression tag |
His 9 | - | expression tag |
His 10 | - | expression tag |
Gly 11 | - | expression tag |
Ser 12 | - | expression tag |
B: 68 - 270 (UniProt: Q9Y478)
PDB | External Database | Details |
---|---|---|
Met 67 | - | expression tag |
Asp 108 | Ser 108 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 117863.2 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1955.1 | |
All* | Total formula weight | 119818.3 |