5XEZ

Structure of the Full-length glucagon class B G protein-coupled receptor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Glucagon receptor,Endolysin,Glucagon receptor	polymer	574	65784.1	2	UniProt (P47871) UniProt (D9IEF7) Pfam (PF02793) Pfam (PF00002) Pfam (PF00959) UniProt (by SIFTS) (P00720)	Homo sapiens (Human)	GL-R,Lysis protein,Lysozyme,Muramidase,GL-R
2	C, E (C, H)	Antibody, mAb1, heavy chain	polymer	231	24978.0	2		Homo sapiens
3	D, F (D, L)	Antibody, mAb1, light chain	polymer	214	23263.8	2		Homo sapiens
4	G, H, I, J, K (E, F, G, I, J)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	5	In PDB GlyTouCan (G42666HT)
5	L, N, O (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
6	M, P (A, B)	4-{[(4-cyclohexylphenyl){[3-(methylsulfonyl)phenyl]carbamoyl}amino]methyl}-N-(1H-tetrazol-5-yl)benzamide	non-polymer		573.7	2	Chemie (97V)

Sequence modifications

A, B: 27 - 256 (UniProt: P47871)

PDB	External Database	Details
Gly 24	-	expression tag
Ala 25	-	expression tag
Pro 26	-	expression tag

A, B: 1002 - 1161 (UniProt: D9IEF7)

PDB	External Database	Details
Thr 1054	Cys 54	engineered mutation
Ala 1097	Cys 97	engineered mutation

A, B: 260 - 432 (UniProt: P47871)

PDB	External Database	Details
Glu 433	-	expression tag
Phe 434	-	expression tag
Leu 435	-	expression tag
Glu 436	-	expression tag
Val 437	-	expression tag
Leu 438	-	expression tag
Phe 439	-	expression tag
Gln 440	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	228051.7
Branched	Number of molecules	5
	Total formula weight	2122.0
Non-Polymers*	Number of molecules	5
	Total formula weight	1811.0
All*	Total formula weight	231984.6

*Water molecules are not included.