5OCA
PCSK9:Fab Complex with Dextran Sulfate
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Proprotein convertase subtilisin/kexin type 9 | polymer | 126 | 14107.8 | 1 | UniProt (Q8NBP7) Pfam (PF05922) In PDB | Homo sapiens (Human) | Neural apoptosis-regulated convertase 1,NARC-1,Proprotein convertase 9,PC9,Subtilisin/kexin-like protease PC9 |
2 | B | Proprotein convertase subtilisin/kexin type 9 | polymer | 540 | 57328.6 | 1 | UniProt (Q8NBP7) Pfam (PF00082) Pfam (PF18459) Pfam (PF18464) Pfam (PF18463) In PDB | Homo sapiens (Human) | Neural apoptosis-regulated convertase 1,NARC-1,Proprotein convertase 9,PC9,Subtilisin/kexin-like protease PC9 |
3 | H | Fab from LDLR competitive antibody: Heavy chain | polymer | 238 | 25489.3 | 1 | Homo sapiens (Human) | ||
4 | L | Fab from LDLR competitive antibody: Light chain | polymer | 217 | 22626.9 | 1 | Homo sapiens (Human) | ||
5 | C | 2,3,4-tri-O-sulfo-beta-D-altropyranose-(1-6)-2,3-di-O-sulfo-alpha-L-glucopyranose | branched | 742.6 | 1 | In PDB BIRD (PRD_900071) GlyTouCan (G96300CN) | Heparan sulfate disaccharide | ||
6 | B | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
7 | water | water | 18.0 | 788 | Chemie (HOH) |
Sequence modifications
A: 31 - 152 (UniProt: Q8NBP7)
B: 153 - 692 (UniProt: Q8NBP7)
PDB | External Database | Details |
---|---|---|
Gly 27 | - | expression tag |
Ala 28 | - | expression tag |
Met 29 | - | expression tag |
Gly 30 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ile 474 | Val 474 | conflict |
Ala 533 | Asn 533 | conflict |
Gly 620 | Glu 620 | conflict |
Glu 670 | Gly 670 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 119552.6 | |
Branched | Number of molecules | 1 |
Total formula weight | 742.6 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 46.0 | |
All* | Total formula weight | 120341.2 |