5O2D
PARP14 Macrodomain 2 with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Poly [ADP-ribose] polymerase 14 | polymer | 200 | 21593.5 | 1 | UniProt (Q460N5) Pfam (PF01661) | Homo sapiens (Human) | PARP-14,ADP-ribosyltransferase diphtheria toxin-like 8,ARTD8,B aggressive lymphoma protein 2 |
| 2 | B (A) | ~{N}-[2-(9~{H}-carbazol-1-yl)phenyl]methanesulfonamide | non-polymer | 336.4 | 1 | Chemie (9HH) | |||
| 3 | C (A) | water | water | 18.0 | 130 | Chemie (HOH) |
Sequence modifications
A: 994 - 1191 (UniProt: Q460N5)
| PDB | External Database | Details |
|---|---|---|
| Ser 992 | - | expression tag |
| Met 993 | - | expression tag |
| Ser 1048 | Lys 1048 | engineered mutation |
| Ser 1154 | Lys 1154 | engineered mutation |
| Ser 1158 | Lys 1158 | engineered mutation |
| Ser 1162 | Lys 1162 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 21593.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 336.4 | |
| All* | Total formula weight | 21929.9 |
