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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5LZS

Structure of the mammalian ribosomal elongation complex with aminoacyl-tRNA, eEF1A, and didemnin B

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AuL2polymer25728088.91UniProt (G1TT27)
Pfam (PF00181)
Pfam (PF03947)
In PDB		Oryctolagus cuniculus (Rabbit)
2BuL3polymer40346108.01UniProt (G1TL06)
Pfam (PF00297)
In PDB		Oryctolagus cuniculus (Rabbit)
3CuL4polymer42547727.61UniProt (G1SVW5)
Pfam (PF00573)
Pfam (PF14374)
In PDB		Oryctolagus cuniculus (Rabbit)
4D60S ribosomal protein L5polymer29734481.81UniProt (G1SYJ6)
Pfam (PF17144)
Pfam (PF14204)
In PDB		Oryctolagus cuniculus (Rabbit)
5E60S ribosomal protein L6polymer29133028.31UniProt (G1SKF7)
Pfam (PF03868)
Pfam (PF01159)
In PDB		Oryctolagus cuniculus (Rabbit)
6FuL30polymer24729201.81UniProt (G1TUB1)
Pfam (PF08079)
Pfam (PF00327)
In PDB		Oryctolagus cuniculus (Rabbit)
7GeL8polymer31936221.51UniProt (G1STW0)
Pfam (PF01248)
In PDB		Oryctolagus cuniculus (Rabbit)
8HuL6polymer19221871.41UniProt (G1TX33)
Pfam (PF00347)
UniProt (by SIFTS) (G1SWI6)
In PDB		Oryctolagus cuniculus (Rabbit)
9IRibosomal protein L10 (Predicted)polymer21424643.11UniProt (B7NZQ2)
Pfam (PF00252)
In PDB		Oryctolagus cuniculus (Rabbit)Uncharacterized protein
10JuL5polymer17820288.51UniProt (G1TUB8)
Pfam (PF00281)
Pfam (PF00673)
In PDB		Oryctolagus cuniculus (Rabbit)
11LeL13polymer21124331.71Oryctolagus cuniculus (Rabbit)
12MeL14polymer21823870.51UniProt (G1SZ12)
Pfam (PF01929)
In PDB		Oryctolagus cuniculus (Rabbit)
13NRibosomal protein L15polymer20424207.31UniProt (G1T0C1)
Pfam (PF00827)
In PDB		Oryctolagus cuniculus (Rabbit)
14OuL13polymer20323533.31Oryctolagus cuniculus (Rabbit)
15PuL22polymer18421444.21UniProt (G1TVT6)
Pfam (PF00237)
In PDB		Oryctolagus cuniculus (Rabbit)
16QeL18polymer18821699.71Oryctolagus cuniculus (Rabbit)
17ReL19polymer19623535.31Oryctolagus cuniculus (Rabbit)
18SeL20polymer17620827.61Oryctolagus cuniculus (Rabbit)
19TeL21polymer16018610.01UniProt (G1SHQ2)
Pfam (PF01157)
In PDB		Oryctolagus cuniculus (Rabbit)
20UeL22polymer12814813.01Oryctolagus cuniculus (Rabbit)
21VuL14polymer14014892.51UniProt (G1T6D1)
Pfam (PF00238)
In PDB		Oryctolagus cuniculus (Rabbit)
22WuL24polymer15717825.11UniProt (G1SE28)
Pfam (PF01246)
In PDB		Oryctolagus cuniculus (Rabbit)
23XuL23polymer15617768.21UniProt (G1SE76)
Pfam (PF03939)
Pfam (PF00276)
In PDB		Oryctolagus cuniculus (Rabbit)
24YuL24polymer14517303.41UniProt (G1SQH0)
Pfam (PF16906)
Pfam (PF00467)
In PDB		Oryctolagus cuniculus (Rabbit)
25Z60S ribosomal protein L27polymer13615835.81UniProt (G1TXF6)
Pfam (PF00467)
Pfam (PF01777)
In PDB		Oryctolagus cuniculus (Rabbit)
26auL15polymer14816620.61UniProt (G1SNY0)
Pfam (PF00828)
In PDB		Oryctolagus cuniculus (Rabbit)
27beL29polymer24526708.71UniProt (G1SGR6)
Pfam (PF01779)
In PDB		Oryctolagus cuniculus (Rabbit)
28ceL30polymer11512807.11UniProt (G1TDL2)
Pfam (PF01248)
In PDB		Oryctolagus cuniculus (Rabbit)
29deL31polymer12514494.91UniProt (G1SHG0)
Pfam (PF01198)
In PDB		Oryctolagus cuniculus (Rabbit)
30eeL32polymer13515898.91UniProt (G1U437)
Pfam (PF01655)
UniProt (by SIFTS) (G1TUN8)
In PDB		Oryctolagus cuniculus (Rabbit)
31feL33polymer11012580.81UniProt (G1SF08)
Pfam (PF01247)
In PDB		Oryctolagus cuniculus (Rabbit)
32geL34polymer11613196.91UniProt (G1U945)
Pfam (PF01199)
In PDB		Oryctolagus cuniculus (Rabbit)
33huL29polymer12314566.61UniProt (G1SIT5)
Pfam (PF00831)
In PDB		Oryctolagus cuniculus (Rabbit)
34i60S ribosomal protein L36polymer10512263.81UniProt (G1TTQ5)
Pfam (PF01158)
In PDB		Oryctolagus cuniculus (Rabbit)
35jRibosomal protein L37polymer9711111.01UniProt (U3KPD5)
Pfam (PF01907)
In PDB		Oryctolagus cuniculus (Rabbit)
36keL38polymer708238.91Oryctolagus cuniculus (Rabbit)
37leL39polymer516455.81UniProt (G1TTN1)
Pfam (PF00832)
In PDB		Oryctolagus cuniculus (Rabbit)
38meL40polymer10211699.81Oryctolagus cuniculus (Rabbit)
39n60s ribosomal protein l41polymer253473.51Oryctolagus cuniculus (Rabbit)eL41
40oeL42polymer10612477.01UniProt (G1U344)
Pfam (PF00935)
UniProt (by SIFTS) (G1T040)
In PDB		Oryctolagus cuniculus (Rabbit)
41peL43polymer9210299.41UniProt (G1SY53)
Pfam (PF01780)
In PDB		Oryctolagus cuniculus (Rabbit)
42reL28polymer13715783.61UniProt (G1U7L1)
Pfam (PF01778)
In PDB		Oryctolagus cuniculus (Rabbit)
43suL10polymer31834380.51Oryctolagus cuniculus (Rabbit)
44tuL11polymer16517847.61UniProt (G1SMR7)
Pfam (PF03946)
Pfam (PF00298)
In PDB		Oryctolagus cuniculus (Rabbit)
452, iitRNApolymer7624436.62Oryctolagus cuniculus (Rabbit)
463E-site tRNApolymer7524102.31Oryctolagus cuniculus (Rabbit)
47528S ribosomal RNApolymer35431148115.41Oryctolagus cuniculus (Rabbit)
4875S ribosomal RNApolymer12038691.91Oryctolagus cuniculus (Rabbit)
4985.8S ribosomal RNApolymer15650143.61Oryctolagus cuniculus (Rabbit)
50918S ribosomal RNApolymer1869602776.91Oryctolagus cuniculus (Rabbit)
51AAuS2polymer29532958.01Oryctolagus cuniculus (Rabbit)
52BB40S ribosomal protein S3apolymer26430002.11UniProt (G1SS70)
Pfam (PF01015)
In PDB		Oryctolagus cuniculus (Rabbit)
53CCuS5polymer29331327.41Oryctolagus cuniculus (Rabbit)
54DDuS4polymer24326715.31UniProt (G1TNM3)
Pfam (PF00189)
Pfam (PF07650)
In PDB		Oryctolagus cuniculus (Rabbit)
55EE40S ribosomal protein S4polymer26329654.91Oryctolagus cuniculus (Rabbit)
56FFUncharacterized proteinpolymer20422913.51UniProt (G1TFM5)
Pfam (PF00177)
In PDB		Oryctolagus cuniculus (Rabbit)
57GG40S ribosomal protein S6polymer24928751.91UniProt (G1TM55)
Pfam (PF01092)
In PDB		Oryctolagus cuniculus (Rabbit)
58HHuS7polymer19422168.91UniProt (G1SVB0)
Pfam (PF01251)
In PDB		Oryctolagus cuniculus (Rabbit)
59II40S ribosomal protein S8polymer20824263.41UniProt (G1TJW1)
Pfam (PF01201)
In PDB		Oryctolagus cuniculus (Rabbit)
60JJRibosomal protein S9 (Predicted)polymer19422641.61UniProt (B7NZS8)
Pfam (PF00163)
Pfam (PF01479)
In PDB		Oryctolagus cuniculus (Rabbit)
61KKeS10polymer16518933.81UniProt (G1TPV3)
Pfam (PF03501)
In PDB		Oryctolagus cuniculus (Rabbit)
62LLuS17polymer15818468.81UniProt (G1TRM4)
Pfam (PF16205)
Pfam (PF00366)
In PDB		Oryctolagus cuniculus (Rabbit)
63MM40S ribosomal protein S12polymer13214539.01UniProt (G1SFR8)
Pfam (PF01248)
In PDB		Oryctolagus cuniculus (Rabbit)
64NNuS15polymer15117259.41UniProt (G1SP51)
Pfam (PF08069)
Pfam (PF00312)
In PDB		Oryctolagus cuniculus (Rabbit)
65OOuS11polymer16818134.01UniProt (G1T1F0)
Pfam (PF00411)
In PDB		Oryctolagus cuniculus (Rabbit)
66PPuS19polymer14517049.21UniProt (G1U0Q2)
Pfam (PF00203)
In PDB		Oryctolagus cuniculus (Rabbit)
67QQuS9polymer14616477.41UniProt (G1SGX4)
Pfam (PF00380)
In PDB		Oryctolagus cuniculus (Rabbit)
68RReS17polymer13515552.11UniProt (G1TU13)
Pfam (PF00833)
In PDB		Oryctolagus cuniculus (Rabbit)
69SSuS13polymer15217759.81UniProt (G1TPG3)
Pfam (PF00416)
In PDB		Oryctolagus cuniculus (Rabbit)
70TTeS19polymer14516106.61UniProt (G1TN62)
Pfam (PF01090)
In PDB		Oryctolagus cuniculus (Rabbit)
71UUuS10polymer11913398.81UniProt (G1SIZ2)
Pfam (PF00338)
In PDB		Oryctolagus cuniculus (Rabbit)
72VVeS21polymer839124.41Oryctolagus cuniculus (Rabbit)
73WWuS8polymer13014865.61UniProt (G1TG89)
Pfam (PF00410)
In PDB		Oryctolagus cuniculus (Rabbit)
74XXuS12polymer14315844.71Oryctolagus cuniculus (Rabbit)
75YYeS24polymer13015107.91Oryctolagus cuniculus (Rabbit)
76ZZeS25polymer12513776.21UniProt (G1TDB3)
Pfam (PF03297)
In PDB		Oryctolagus cuniculus (Rabbit)
77aaeS26polymer11513047.51Oryctolagus cuniculus (Rabbit)
78bb40S ribosomal protein S27polymer849480.21UniProt (G1TZ76)
Pfam (PF01667)
In PDB		Oryctolagus cuniculus (Rabbit)
79cceS28polymer697855.11UniProt (G1TIB4)
Pfam (PF01200)
In PDB		Oryctolagus cuniculus (Rabbit)
80dduS14polymer566690.81UniProt (G1U7M4)
Pfam (PF00253)
In PDB		Oryctolagus cuniculus (Rabbit)
81eeeS30polymer13314498.91UniProt (G1T8A2)
Pfam (PF00240)
Pfam (PF04758)
In PDB		Oryctolagus cuniculus (Rabbit)
82ffeS31polymer15618004.01UniProt (G1SK22)
Pfam (PF00240)
Pfam (PF01599)
In PDB		Oryctolagus cuniculus (Rabbit)
83ggRACK1polymer31735115.71UniProt (G1SJB4)
Pfam (PF00400)
In PDB		Oryctolagus cuniculus (Rabbit)
84hhmRNApolymer103139.91Oryctolagus cuniculus (Rabbit)
85jjElongation factor 1-alpha 1polymer46250294.81UniProt (P68105)
Pfam (PF00009)
Pfam (PF03144)
Pfam (PF03143)
In PDB		Oryctolagus cuniculus (Rabbit)EF-1-alpha-1,Elongation factor Tu,EF-Tu,Eukaryotic elongation factor 1 A-1,eEF1A-1
865, 7, 9, aa, 8...MAGNESIUM IONnon-polymer24.3276Chemie (MG)
87aa, dd, ff, g, j...ZINC IONnon-polymer65.48Chemie (ZN)
88jjGUANOSINE-5'-DIPHOSPHATEnon-polymer443.21Chemie (GDP)
89jj(2~{S})-~{N}-[(2~{R})-1-[[(3~{S},6~{S},8~{S},12~{S},13~{R},16~{S},17~{R},20~{S},23~{S})-13-[(2~{S})-butan-2-yl]-20-[(4-methoxyphenyl)methyl]-6,17,21-trimethyl-3-(2-methylpropyl)-12-oxidanyl-2,5,7,10,15,19,22-heptakis(oxidanylidene)-8-propan-2-yl-9,18-dioxa-1,4,14,21-tetrazabicyclo[21.3.0]hexacosan-16-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-~{N}-methyl-1-[(2~{S})-2-oxidanylpropanoyl]pyrrolidine-2-carboxamidenon-polymer1112.41Chemie (7C4)
Sequence modifications
B: 2 - 403 (UniProt: G1TL06)
PDBExternal DatabaseDetails
Met 1-initiating methionine
C: 1 - 378 (UniProt: G1SVW5)
C: 379 - 425 (PDB: 5LZS)
D: 2 - 297 (UniProt: G1SYJ6)
PDBExternal DatabaseDetails
Met 1-initiating methionine
F: 1 - 247 (UniProt: G1TUB1)
PDBExternal DatabaseDetails
Arg 61Gly 61conflict
Arg 93Gly 93conflict
Met 131Val 131conflict
Ile 153Val 153conflict
G: 1 - 77 (PDB: 5LZS)
G: 78 - 319 (UniProt: G1STW0)
PDBExternal DatabaseDetails
Gly 244Cys 167conflict
a: 1 - 148 (UniProt: G1SNY0)
PDBExternal DatabaseDetails
Met 1Gln 1conflict
b: 1 - 226 (UniProt: G1SGR6)
b: 227 - 245 (PDB: 5LZS)
II: 1 - 208 (UniProt: G1TJW1)
PDBExternal DatabaseDetails
Arg 47Gly 47conflict
OO: -16 - -5 (PDB: 5LZS)
OO: -4 - 151 (UniProt: G1T1F0)
TT: 1 - 145 (UniProt: G1TN62)
PDBExternal DatabaseDetails
Gly 119Trp 119conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains86
Total formula weight3487688.5
Non-Polymers*Number of molecules286
Total formula weight8787.0
All*Total formula weight3496475.5
*Water molecules are not included.

218853

數據於2024-04-24公開中

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