4XEM

Crystal Structure of wild type human AlaRS catalytic domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Alanine--tRNA ligase, cytoplasmic	polymer	475	53314.2	1	UniProt (P49588) Pfam (PF01411) In PDB	Homo sapiens (Human)	Alanyl-tRNA synthetase,AlaRS,Renal carcinoma antigen NY-REN-42
2	A	'5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE	non-polymer		417.4	1	Chemie (A5A)
3	A	1,2-ETHANEDIOL	non-polymer		62.1	5	Chemie (EDO)
4		water	water		18.0	490	Chemie (HOH)

Sequence modifications

A: 1 - 455 (UniProt: P49588)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	53314.2
Non-Polymers*	Number of molecules	6
	Total formula weight	727.7
All*	Total formula weight	54041.9

*Water molecules are not included.