4U4Q

Crystal structure of Homoharringtonine bound to the yeast 80S ribosome

This is a large structure.

Entity

Chain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
2, 618S ribosomal RNApolymer1800579761.92
GenBank (U53879.1)
Saccharomyces cerevisiae ATCC 204508 / S288cRNA (1750-MER)
S0, s040S ribosomal protein S0-Apolymer25127920.12
UniProt (P32905)
Pfam (PF00318)
Saccharomyces cerevisiae ATCC 204508 / S288cNucleic acid-binding protein NAB1A
S1, s140S ribosomal protein S1-Apolymer25428667.32
UniProt (P33442)
Pfam (PF01015)
Saccharomyces cerevisiae ATCC 204508 / S288cRP10A
S2, s240S ribosomal protein S2polymer25327359.62
UniProt (P25443)
Pfam (PF00333)
Pfam (PF03719)
Saccharomyces cerevisiae ATCC 204508 / S288cOmnipotent suppressor protein SUP44,RP12,S4,YS5
S3, s340S ribosomal protein S3polymer23926411.62
UniProt (P05750)
Pfam (PF00189)
Pfam (PF07650)
Saccharomyces cerevisiae ATCC 204508 / S288cRP13,YS3
S4, s440S ribosomal protein S4-Apolymer26029338.12
UniProt (P0CX35)
Pfam (PF00467)
Pfam (PF00900)
Pfam (PF01479)
Pfam (PF08071)
Pfam (PF16121)
Saccharomyces cerevisiae ATCC 204508 / S288cRP5,S7,YS6
S5, s540S ribosomal protein S5polymer22424941.42
UniProt (P26783)
Pfam (PF00177)
Saccharomyces cerevisiae ATCC 204508 / S288cRP14,S2,YS8
S6, s640S ribosomal protein S6-Apolymer23627054.52
UniProt (P0CX37)
Pfam (PF01092)
Saccharomyces cerevisiae ATCC 204508 / S288cRP9,S10,YS4
S7, s740S ribosomal protein S7-Apolymer18921527.02
UniProt (P26786)
Pfam (PF01251)
Saccharomyces cerevisiae ATCC 204508 / S288cRP30,RP40
S8, s840S ribosomal protein S8-Apolymer20022537.82
UniProt (P0CX39)
Pfam (PF01201)
Saccharomyces cerevisiae ATCC 204508 / S288cRP19,S14,YS9
S9, s940S ribosomal protein S9-Apolymer19622356.72
UniProt (O13516)
Pfam (PF01479)
Saccharomyces cerevisiae ATCC 204508 / S288cRP21,S13,YP28,YS11
C0, c040S ribosomal protein S10-Apolymer10512771.52
UniProt (Q08745)
Pfam (PF03501)
Saccharomyces cerevisiae ATCC 204508 / S288c
C1, c140S ribosomal protein S11-Apolymer15517668.82
UniProt (P0CX47)
Pfam (PF00366)
Pfam (PF16205)
Saccharomyces cerevisiae ATCC 204508 / S288cRP41,S18,YS12
C2, c240S ribosomal protein S12polymer14215385.52
UniProt (P48589)
Pfam (PF01248)
Saccharomyces cerevisiae ATCC 204508 / S288c
C3, c340S ribosomal protein S13polymer15016928.72
UniProt (P05756)
Pfam (PF00312)
Saccharomyces cerevisiae ATCC 204508 / S288cS27a,YS15
C4, c440S ribosomal protein S14-Apolymer13614431.52
UniProt (P06367)
Pfam (PF00411)
Saccharomyces cerevisiae ATCC 204508 / S288cRP59A
C5, c540S ribosomal protein S15polymer14115900.72
UniProt (Q01855)
Pfam (PF00203)
Saccharomyces cerevisiae ATCC 204508 / S288cRIG protein,RP52,S21,YS21
C6, c640S ribosomal protein S16-Apolymer14215746.32
UniProt (P0CX51)
Pfam (PF00380)
Saccharomyces cerevisiae ATCC 204508 / S288cRP61R
C7, c740S ribosomal protein S17-Apolymer13615820.42
UniProt (P02407)
Pfam (PF00833)
Saccharomyces cerevisiae ATCC 204508 / S288cRP51A
C8, c840S ribosomal protein S18-Apolymer14516940.42
UniProt (P0CX55)
Pfam (PF00416)
Saccharomyces cerevisiae ATCC 204508 / S288c
C9, c940S ribosomal protein S19-Apolymer14315810.92
UniProt (P07280)
Pfam (PF01090)
Saccharomyces cerevisiae ATCC 204508 / S288cRP55A,S16a,YP45,YS16A
D0, d040S ribosomal protein S20polymer12013797.92
UniProt (P38701)
Pfam (PF00338)
Saccharomyces cerevisiae ATCC 204508 / S288c
D1, d140S ribosomal protein S21-Apolymer879758.82
UniProt (P0C0V8)
Pfam (PF01249)
Saccharomyces cerevisiae ATCC 204508 / S288cS26,YS25
D2, d240S ribosomal protein S22-Apolymer12914518.92
UniProt (P0C0W1)
Pfam (PF00410)
Saccharomyces cerevisiae ATCC 204508 / S288cRP50,S24,YP58,YS22
D3, d340S ribosomal protein S23-Apolymer14415942.72
UniProt (P0CX29)
Pfam (PF00164)
Saccharomyces cerevisiae ATCC 204508 / S288cRP37,S28,YS14
D4, d440S ribosomal protein S24-Apolymer13415231.72
UniProt (P0CX31)
Pfam (PF01282)
Saccharomyces cerevisiae ATCC 204508 / S288cRP50
D5, d540S ribosomal protein S25-Apolymer10711936.12
UniProt (Q3E792)
Pfam (PF03297)
Saccharomyces cerevisiae ATCC 204508 / S288cRP45,S31,YS23
D6, d640S ribosomal protein S26-Bpolymer9711023.02
UniProt (P39939)
Saccharomyces cerevisiae ATCC 204508 / S288c
D7, d740S ribosomal protein S27-Apolymer818762.22
UniProt (P35997)
Pfam (PF01667)
Saccharomyces cerevisiae ATCC 204508 / S288cRP61,YS20
D8, d840S ribosomal protein S28-Apolymer667474.72
UniProt (Q3E7X9)
Pfam (PF01200)
Saccharomyces cerevisiae ATCC 204508 / S288cS33,YS27
D9, d940S ribosomal protein S29-Apolymer556544.52
UniProt (P41057)
Pfam (PF00253)
Saccharomyces cerevisiae ATCC 204508 / S288cS36,YS29
E040S ribosomal protein S30-Apolymer606779.11
UniProt (P0CX33)
Pfam (PF04758)
Saccharomyces cerevisiae ATCC 204508 / S288c
E1, e1Ubiquitin-40S ribosomal protein S31polymer768703.52
UniProt (P05759)
Pfam (PF01599)
Saccharomyces cerevisiae ATCC 204508 / S288c
SR, sRGuanine nucleotide-binding protein subunit beta-like proteinpolymer31834710.02
UniProt (P38011)
Pfam (PF00400)
Saccharomyces cerevisiae ATCC 204508 / S288cReceptor for activated C kinase,Receptor of activated protein kinase C 1,RACK1
SM, sMSuppressor protein STM1polymer27330048.02
UniProt (P39015)
Pfam (PF09598)
Saccharomyces cerevisiae ATCC 204508 / S288c3BP1,GU4 nucleic-binding protein 2,G4p2 protein,POP2 multicopy suppressor protein 4,Ribosomal subunits association factor,AF,TOM1 suppressor protein 1,Triplex-binding protein 1
1, 525S ribosomal RNApolymer33961097493.92
TPG (329138943)
Saccharomyces cerevisiae ATCC 204508 / S288cRNA (3149-MER)
3, 75S ribosomal RNApolymer12138951.12
TPG (329138943)
Saccharomyces cerevisiae ATCC 204508 / S288cRNA (121-MER)
4, 85.8S ribosomal RNApolymer15850682.92
GenBank (HG970743.1)
Saccharomyces cerevisiae ATCC 204508 / S288cRNA (158-MER)
L2, l260S ribosomal protein L2-Apolymer25327332.42
UniProt (P0CX45)
Pfam (PF00181)
Pfam (PF03947)
Saccharomyces cerevisiae ATCC 204508 / S288cL5,RP8,YL6
L3, l360S ribosomal protein L3polymer38643719.62
UniProt (P14126)
Saccharomyces cerevisiae ATCC 204508 / S288cMaintenance of killer protein 8,RP1,Trichodermin resistance protein,YL1
L4, l460S ribosomal protein L4-Apolymer36139027.92
UniProt (P10664)
Pfam (PF00573)
Pfam (PF14374)
Saccharomyces cerevisiae ATCC 204508 / S288cL2,RP2,YL2
L5, l560S ribosomal protein L5polymer29633633.62
UniProt (P26321)
Pfam (PF14204)
Pfam (PF17144)
Saccharomyces cerevisiae ATCC 204508 / S288cL1,L1a,Ribosomal 5S RNA-binding protein,YL3
L6, l660S ribosomal protein L6-Apolymer17519869.42
UniProt (Q02326)
Pfam (PF01159)
Saccharomyces cerevisiae ATCC 204508 / S288cL17,RP18,YL16
L7, l760S ribosomal protein L7-Apolymer24327555.12
UniProt (P05737)
Pfam (PF00327)
Pfam (PF08079)
Saccharomyces cerevisiae ATCC 204508 / S288cL6,RP11,YL8
L8, l860S ribosomal protein L8-Apolymer25528044.62
UniProt (P17076)
Pfam (PF01248)
Saccharomyces cerevisiae ATCC 204508 / S288cL4,L4-2,L7a-1,Maintenance of killer protein 7,RP6,YL5
L9, l960S ribosomal protein L9-Apolymer19121605.12
UniProt (P05738)
Pfam (PF00347)
Saccharomyces cerevisiae ATCC 204508 / S288cL8,RP24,YL11
M0, m060S ribosomal protein L10polymer22025279.32
UniProt (P41805)
Pfam (PF00252)
Saccharomyces cerevisiae ATCC 204508 / S288cL9,Ubiquinol-cytochrome C reductase complex subunit VI-requiring protein
M1, m160S ribosomal protein L11-Bpolymer17319654.52
UniProt (Q3E757)
Pfam (PF00281)
Pfam (PF00673)
Saccharomyces cerevisiae ATCC 204508 / S288cL16,RP39,YL22
M3, m360S ribosomal protein L13-Apolymer19822473.02
UniProt (Q12690)
Pfam (PF01294)
Saccharomyces cerevisiae ATCC 204508 / S288c
M4, m460S ribosomal protein L14-Apolymer13715063.92
UniProt (P36105)
Pfam (PF01929)
Saccharomyces cerevisiae ATCC 204508 / S288c
M5, m560S ribosomal protein L15-Apolymer20324351.22
UniProt (P05748)
Pfam (PF00827)
Saccharomyces cerevisiae ATCC 204508 / S288cL13,RP15R,YL10,YP18
M6, m660S ribosomal protein L16-Apolymer19822116.02
UniProt (P26784)
Pfam (PF00572)
Saccharomyces cerevisiae ATCC 204508 / S288cL13a,L21,RP22,YL15
M7, m760S ribosomal protein L17-Apolymer18320458.32
UniProt (P05740)
Pfam (PF00237)
Saccharomyces cerevisiae ATCC 204508 / S288cL20A,YL17
M8, m860S ribosomal protein L18-Apolymer18520478.12
UniProt (P0CX49)
Pfam (PF17135)
Saccharomyces cerevisiae ATCC 204508 / S288cRP28
M9, m960S ribosomal protein L19-Apolymer18821631.12
UniProt (P0CX82)
Pfam (PF01280)
Saccharomyces cerevisiae ATCC 204508 / S288cL23,RP15L,RP33,YL14
N0, n060S ribosomal protein L20-Apolymer17220478.92
UniProt (P0CX23)
Pfam (PF01775)
Saccharomyces cerevisiae ATCC 204508 / S288cL18a
N1, n160S ribosomal protein L21-Apolymer15918148.12
UniProt (Q02753)
Saccharomyces cerevisiae ATCC 204508 / S288c
N2, n260S ribosomal protein L22-Apolymer12013580.22
UniProt (P05749)
Pfam (PF01776)
Saccharomyces cerevisiae ATCC 204508 / S288cL1c,RP4,YL31
N3, n360S ribosomal protein L23-Apolymer13614362.82
UniProt (P0CX41)
Pfam (PF00238)
Saccharomyces cerevisiae ATCC 204508 / S288cL17a,YL32
N4, n460S ribosomal protein L24-Apolymer15517661.72
UniProt (P04449)
Pfam (PF01246)
Saccharomyces cerevisiae ATCC 204508 / S288cL30,RP29,YL21
N5, n560S ribosomal protein L25polymer14115656.42
UniProt (P04456)
Pfam (PF00276)
Pfam (PF03939)
Saccharomyces cerevisiae ATCC 204508 / S288cRP16L,YL25,YP42'
N6, n660S ribosomal protein L26-Apolymer12614134.62
UniProt (P05743)
Pfam (PF00467)
Pfam (PF16906)
Saccharomyces cerevisiae ATCC 204508 / S288cL33,YL33
N7, n760S ribosomal protein L27-Apolymer13515437.22
UniProt (P0C2H6)
Pfam (PF01777)
Saccharomyces cerevisiae ATCC 204508 / S288c
N8, n860S ribosomal protein L28polymer14816630.52
UniProt (P02406)
Pfam (PF00828)
Saccharomyces cerevisiae ATCC 204508 / S288cL27a,L29,RP44,RP62,YL24
N9, n960S ribosomal protein L29polymer586560.72
UniProt (P05747)
Pfam (PF01779)
Saccharomyces cerevisiae ATCC 204508 / S288cYL43
O0, o060S ribosomal protein L30polymer10411299.22
UniProt (P14120)
Pfam (PF01248)
Saccharomyces cerevisiae ATCC 204508 / S288cL32,RP73,YL38
O1, o160S ribosomal protein L31-Apolymer11212849.02
UniProt (P0C2H8)
Pfam (PF01198)
Saccharomyces cerevisiae ATCC 204508 / S288cL34,YL28
O2, o260S ribosomal protein L32polymer12914678.22
UniProt (P38061)
Pfam (PF01655)
Saccharomyces cerevisiae ATCC 204508 / S288c
O3, o360S ribosomal protein L33-Apolymer10612045.92
UniProt (P05744)
Pfam (PF01247)
Saccharomyces cerevisiae ATCC 204508 / S288cL37,RP47,YL37
O4, o460S ribosomal protein L34-Apolymer12013542.02
UniProt (P87262)
Saccharomyces cerevisiae ATCC 204508 / S288c
O5, o560S ribosomal protein L35-Apolymer11913811.42
UniProt (P0CX84)
Pfam (PF00831)
Saccharomyces cerevisiae ATCC 204508 / S288c
O6, o660S ribosomal protein L36-Apolymer9911020.12
UniProt (P05745)
Pfam (PF01158)
Saccharomyces cerevisiae ATCC 204508 / S288cL39,YL39
O7, o760S ribosomal protein L37-Apolymer879746.22
UniProt (P49166)
Pfam (PF01907)
Saccharomyces cerevisiae ATCC 204508 / S288cL43,YL35,YP55
O8, o860S ribosomal protein L38polymer778714.42
UniProt (P49167)
Pfam (PF01781)
Saccharomyces cerevisiae ATCC 204508 / S288c
O9, o960S ribosomal protein L39polymer506227.42
UniProt (P04650)
Pfam (PF00832)
Saccharomyces cerevisiae ATCC 204508 / S288cL46,YL40
Q0, q0Ubiquitin-60S ribosomal protein L40polymer526032.32
UniProt (P0CH08)
Pfam (PF01020)
Saccharomyces cerevisiae ATCC 204508 / S288c
Q1, q160S ribosomal protein L41-Apolymer253354.22
UniProt (P0CX86)
Pfam (PF05162)
Saccharomyces cerevisiae ATCC 204508 / S288cL47,YL41
Q2, q260S ribosomal protein L42-Apolymer10512115.52
UniProt (P0CX27)
Pfam (PF00935)
Saccharomyces cerevisiae ATCC 204508 / S288cL41,YL27,YP44
Q3, q360S ribosomal protein L43-Apolymer919981.82
UniProt (P0CX25)
Pfam (PF01780)
Saccharomyces cerevisiae ATCC 204508 / S288cL37a,YL35
e040S ribosomal protein S30-Apolymer627006.31
UniProt (P0CX33)
Pfam (PF04758)
Saccharomyces cerevisiae ATCC 204508 / S288c
m2Unknown protein chain m2polymer16013634.81
Saccharomyces cerevisiae ATCC 204508 / S288c
p060S acidic ribosomal protein P0polymer31133617.91
UniProt (P05317)
Pfam (PF00428)
Pfam (PF00466)
Pfam (PF17777)
Saccharomyces cerevisiae ATCC 204508 / S288cA0,L10E
p1Unknown protein chain p1polymer474017.91
Saccharomyces cerevisiae ATCC 204508 / S288c
p2Unknown protein chain p2polymer463932.81
Saccharomyces cerevisiae ATCC 204508 / S288c
MAGNESIUM IONnon-polymer24.31411
osmium (III) hexamminenon-polymer286.41133
ZINC IONnon-polymer65.416
(3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxinenon-polymer545.62

Sequence viewer

Contents of the asymmetric unit

PolymersNumber of chains162
Total molecular weight6271433.0
Non-Polymers*Number of molecules2562
Total molecular weight360883.7
All*Total molecular weight6632316.7
*Water molecules are not included.