4EKX

Crystal Structure of YLDV 14L IL-18 Binding Protein in Complex with Human IL-18

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	C, A	14L protein	polymer	116	13733.0	2	UniProt (Q9DHU8) In PDB	Yaba-like disease virus (YLDV)
2	B, D	Interleukin-18	polymer	157	17959.1	2	UniProt (Q14116) Pfam (PF00340) In PDB	Homo sapiens (human)	IL-18, Iboctadekin, Interferon gamma-inducing factor, IFN-gamma-inducing factor, Interleukin-1 gamma, IL-1 gamma
3		water	water		18.0	240	Chemie (HOH)

Sequence modifications

C, A: 22 - 136 (UniProt: Q9DHU8)

PDB	External Database	Details
Met 21	-	EXPRESSION TAG
Ser 87	Cys 87	ENGINEERED MUTATION
Ser 132	Cys 132	ENGINEERED MUTATION

B, D: 1 - 157 (UniProt: Q14116)

PDB	External Database	Details
Ser 38	Cys 74	ENGINEERED MUTATION
Ala 67	Lys 103	ENGINEERED MUTATION
Ser 68	Cys 104	ENGINEERED MUTATION
Ala 69	Glu 105	ENGINEERED MUTATION
Ala 70	Lys 106	ENGINEERED MUTATION
Ala 71	Ile 107	ENGINEERED MUTATION
Ser 76	Cys 112	ENGINEERED MUTATION
Ser 127	Cys 163	ENGINEERED MUTATION

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	63384.3
All*	Total formula weight	63384.3

*Water molecules are not included.