4V06
Crystal structure of human tryptophan hydroxylase 2 (TPH2), catalytic domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | TRYPTOPHAN 5-HYDROXYLASE 2 | polymer | 349 | 40251.7 | 2 | UniProt (Q8IWU9) Pfam (PF00351) | HOMO SAPIENS (HUMAN) | NEURONAL TRYPTOPHAN HYDROXYLASE, TRYPTOPHAN 5-MONOOXYGENASE 2 |
| 2 | C, E (A, B) | IMIDAZOLE | non-polymer | 69.1 | 2 | Chemie (IMD) | |||
| 3 | D, F (A, B) | FE (III) ION | non-polymer | 55.8 | 2 | Chemie (FE) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 111 | Chemie (HOH) |
Sequence modifications
A, B: 148 - 490 (UniProt: Q8IWU9)
| PDB | External Database | Details |
|---|---|---|
| Leu 142 | - | expression tag |
| Tyr 143 | - | expression tag |
| Phe 144 | - | expression tag |
| Gln 145 | - | expression tag |
| Ser 146 | - | expression tag |
| Met 147 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 80503.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 249.9 | |
| All* | Total formula weight | 80753.3 |
