3ZBF
Structure of Human ROS1 Kinase Domain in Complex with Crizotinib
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS | polymer | 322 | 37014.5 | 1 | UniProt (P08922) Pfam (PF07714) In PDB | HOMO SAPIENS (HUMAN) | PROTO-ONCOGENE C-ROS, PROTO-ONCOGENE C-ROS-1, RECEPTOR TYROSINE KINASE C-ROS ONCOGENE 1, C-ROS RECEPTOR TYROSINE KINASE |
2 | A | 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine | non-polymer | 450.3 | 1 | Chemie (VGH) | |||
3 | water | water | 18.0 | 137 | Chemie (HOH) |
Sequence modifications
A: 1934 - 2232 (UniProt: P08922)
PDB | External Database | Details |
---|---|---|
Met 1911 | - | expression tag |
Ala 1912 | - | expression tag |
His 1913 | - | expression tag |
His 1914 | - | expression tag |
His 1915 | - | expression tag |
His 1916 | - | expression tag |
His 1917 | - | expression tag |
His 1918 | - | expression tag |
Asp 1919 | - | expression tag |
Tyr 1920 | - | expression tag |
Gly 1921 | - | expression tag |
Ile 1922 | - | expression tag |
Pro 1923 | - | expression tag |
Thr 1924 | - | expression tag |
Thr 1925 | - | expression tag |
Glu 1926 | - | expression tag |
Asn 1927 | - | expression tag |
Leu 1928 | - | expression tag |
Tyr 1929 | - | expression tag |
Phe 1930 | - | expression tag |
Gln 1931 | - | expression tag |
Gly 1932 | - | expression tag |
Ser 1933 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 37014.5 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 450.3 | |
All* | Total formula weight | 37464.8 |