3F62

Crystal Structure of Human IL-18 in complex with Ectromelia virus IL-18 Binding Protein

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Interleukin 18 binding protein	polymer	109	12368.0	1	UniProt (Q9IW12) Pfam (PF05566) UniProt (by SIFTS) (Q85319) In PDB	Ectromelia virus
2	B	Interleukin-18	polymer	158	18232.5	1	UniProt (Q14116) Pfam (PF00340) In PDB	Homo sapiens (human)	IL-18, Interferon-gamma-inducing factor, IFN-gamma-inducing factor, Interleukin-1 gamma, IL-1 gamma, Iboctadekin
3		water	water		18.0	120	Chemie (HOH)

Sequence modifications

A: 21 - 126 (UniProt: Q9IW12)

PDB	External Database	Details
Gly 18	-	expression tag
Ala 19	-	expression tag
Met 20	-	expression tag

B: 1 - 157 (UniProt: Q14116)

PDB	External Database	Details
Gly 0	-	expression tag
Ser 38	Cys 74	engineered mutation
Ser 68	Cys 104	engineered mutation
Ser 76	Cys 112	engineered mutation
Ser 127	Cys 163	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	30600.5
All*	Total formula weight	30600.5

*Water molecules are not included.