3E50
Crystal structure of human insulin degrading enzyme in complex with transforming growth factor-alpha
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Insulin-degrading enzyme | polymer | 990 | 114715.1 | 2 | UniProt (P14735) Pfam (PF00675) Pfam (PF05193) Pfam (PF16187) In PDB | Homo sapiens (Human) | Insulin protease, Insulinase, Insulysin |
2 | C, D | Protransforming growth factor alpha | polymer | 50 | 5560.2 | 2 | UniProt (P01135) In PDB | Homo sapiens (Human) | Transforming growth factor alpha, TGF-alpha, EGF-like TGF, ETGF, TGF type 1 |
3 | A, D | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
4 | water | water | 18.0 | 568 | Chemie (HOH) |
Sequence modifications
A, B: 42 - 1019 (UniProt: P14735)
PDB | External Database | Details |
---|---|---|
Met 30 | - | expression tag |
His 31 | - | expression tag |
His 32 | - | expression tag |
His 33 | - | expression tag |
His 34 | - | expression tag |
His 35 | - | expression tag |
His 36 | - | expression tag |
Ala 37 | - | expression tag |
Ala 38 | - | expression tag |
Gly 39 | - | expression tag |
Ile 40 | - | expression tag |
Pro 41 | - | expression tag |
Gln 111 | Glu 111 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 240550.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 130.8 | |
All* | Total formula weight | 240681.6 |